Cloned (Comment) | Organism |
---|---|
gene EPHX2, expression of wild-type and mutant enzymes | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
C154Y | single nucleotide polymorphisms of gene EPHX2, the mutation leads to slightly reduced cell death | Mus musculus |
K55R | single nucleotide polymorphisms of gene EPHX2, the mutation leads to slightly reduced cell death | Mus musculus |
additional information | construction of knockout mutants of sEH, phenotypes, overview | Mus musculus |
R103C | single nucleotide polymorphisms of gene EPHX2, the mutation leads to slightly reduced cell death | Mus musculus |
R103C/R287Q | single nucleotide polymorphisms of gene EPHX2, the mutation leads to slightly reduced cell death | Mus musculus |
R287Q | single nucleotide polymorphisms of gene EPHX2, leads to improved tolerance against ischemia in vitro, and inhibition of sEH preserves cardiomyocyte viability, mechanism, overview | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-Phenylchalcone oxide | - |
Mus musculus | |
additional information | sEH inhibition is abolished by STAT3 siRNA | Mus musculus | |
N-adamantanyl-N'-dodecanoic acid urea | - |
Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
soluble | - |
Mus musculus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O | Mus musculus | 14,15-epoxyeicosatrienoic acid, i.e. 14,15-EET, is cytoprotective in vivo, which is in part mediated by STAT3, overview | (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P34914 | C57BL/6J mice, gene EPHX2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cardiomyocyte | - |
Mus musculus | - |
heart | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O | - |
Mus musculus | (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid | - |
? | |
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O | 14,15-epoxyeicosatrienoic acid, i.e. 14,15-EET, is cytoprotective in vivo, which is in part mediated by STAT3, overview | Mus musculus | (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SEH | - |
Mus musculus |