Literature summary for 3.3.2.10 extracted from

Monti, J.; Fischer, J.; Paskas, S.; Heinig, M.; Schulz, H.; Goesele, C.; Heuser, A.; Fischer, R.; Schmidt, C.; Schirdewan, A.; Gross, V.; Hummel, O.; Maatz, H.; Patone, G.; Saar, K.; Vingron, M.; Weldon, S.M.; Lindpaintner, K.; Hammock, B.D.; Rohde, K.; Dietz, R.; Cook, S.A.; Schunck, W.H.; Luft, F.C.; Hub, H.u.b.n.
Soluble epoxide hydrolase is a susceptibility factor for heart failure in a rat model of human disease (2008), Nat. Genet., 40, 529-537.

Application

Application	Comment	Organism
medicine	soluble epoxide hydrolase is a susceptibility factor for heart failure	Rattus norvegicus
medicine	soluble epoxide hydrolase is a susceptibility factor for heart failure, EPHX2 mRNA expression is down-regulated in individuals with heart failure	Homo sapiens

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Rattus norvegicus	-	-	-

Source Tissue	Comment	Organism	Textmining
heart	-	Rattus norvegicus	-
myocardium	-	Homo sapiens	-

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(5Z,8Z,11Z)-14,15-epoxyeicosa-5,8,11-trienoic acid + H2O	i.e. 14,15-EET	Homo sapiens	(5Z,8Z,11Z)-14,15-dihydroxyeicosa-5,8,11-trienoic acid	i.e. 14,15-DHET	?
(5Z,8Z,11Z)-14,15-epoxyeicosa-5,8,11-trienoic acid + H2O	i.e. 14,15-EET	Rattus norvegicus	(5Z,8Z,11Z)-14,15-dihydroxyeicosa-5,8,11-trienoic acid	i.e. 14,15-DHET	?

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Release 2023.1 (January 2023)