Application | Comment | Organism |
---|---|---|
medicine | sEH inhibitors may be useful in the treatment of patients with atherosclerotic cardiovascular disease | Mus musculus |
medicine | sEH inhibitors may be useful in the treatment of patients with atherosclerotic cardiovascular disease | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
- |
Mus musculus |
- |
Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-adamantan-3-(5-(2-(2-ethylethoxy)ethoxy)pentyl)urea | highly potent and selective sEH inhibitor | Homo sapiens | |
1-adamantan-3-(5-(2-(2-ethylethoxy)ethoxy)pentyl)urea | highly potent and selective sEH inhibitor | Mus musculus | |
12-(3-adamantan-1-yl-ureido)dodecanoic acid | potent transition state inhibitor of sEH | Homo sapiens | |
12-(3-adamantan-1-yl-ureido)dodecanoic acid | potent transition state inhibitor of sEH | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Mus musculus |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(5Z,11Z,14Z)-8,9-epoxyeicosa-5,11,14-trienoic acid + H2O | i.e. 8,9-EET | Mus musculus | (5Z,11Z,14Z)-8,9-dihydroxyeicosa-5,11,14-trienoic acid | i.e. 8,9-DHET | ? | |
(5Z,8Z,11Z)-14,15-epoxyeicosa-5,8,11-trienoic acid + H2O | i.e. 14,15-EET | Mus musculus | (5Z,8Z,11Z)-14,15-dihydroxyeicosa-5,8,11-trienoic acid | i.e. 14,15-DHET | ? | |
(5Z,8Z,14Z)-11,12-epoxyeicosa-5,8,14-trienoic acid + H2O | i.e. 11,12-EET | Mus musculus | (5Z,8Z,14Z)-11,12-dihydroxyeicosa-5,8,14-trienoic acid | i.e. 11,12-DHET | ? | |
11,12-epoxyeicosatrienoic acid + H2O | - |
Homo sapiens | 11,12-dihydroxyeicosatrienoic acid | - |
? | |
14,15-epoxyeicosatrienoic acid + H2O | - |
Homo sapiens | 14,15-dihydroxyeicosatrienoic acid | - |
? | |
5,6-epoxyeicosatrienoic acid + H2O | - |
Mus musculus | 5,6-hydroxyeicosatrienoic acid | - |
? | |
5,6-epoxyeicosatrienoic acid + H2O | - |
Homo sapiens | 5,6-hydroxyeicosatrienoic acid | - |
? | |
8,9-epoxyeicosatrienoic acid + H2O | - |
Homo sapiens | 8,9-hydroxyeicosatrienoic acid | - |
? | |
alpha-cyanocarbonate epoxide + H2O | - |
Mus musculus | ? | - |
? | |
alpha-cyanocarbonate epoxide + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SEH | - |
Mus musculus |
SEH | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000003 | - |
purified recombinant enzyme | Homo sapiens | 12-(3-adamantan-1-yl-ureido)dodecanoic acid | |
0.000003 | - |
purified recombinant enzyme | Mus musculus | 1-adamantan-3-(5-(2-(2-ethylethoxy)ethoxy)pentyl)urea | |
0.00001 | - |
purified recombinant enzyme | Mus musculus | 12-(3-adamantan-1-yl-ureido)dodecanoic acid | |
0.000014 | - |
purified recombinant enzyme | Homo sapiens | 1-adamantan-3-(5-(2-(2-ethylethoxy)ethoxy)pentyl)urea |