Literature summary for 3.3.2.10 extracted from

Keserue, B.; Barbosa-Sicard, E.; Popp, R.; Fisslthaler, B.; Dietrich, A.; Gudermann, T.; Hammock, B.D.; Falck, J.R.; Weissmann, N.; Busse, R.; Fleming, I.
Epoxyeicosatrienoic acids and the soluble epoxide hydrolase are determinants of pulmonary artery pressure and the acute hypoxic pulmonary vasoconstrictor response (2008), FASEB J., 22, 4306-4315.

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Application

Application	Comment	Organism
medicine	the activity of sEH plays a significant role in determining the magnitude of acute hypoxic vasoconstriction	Mus musculus

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in rat pulmonary artery smooth muscle cells	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
1-adamantan-1-yl-3-[5-[2-(2-ethoxyethoxy)ethoxy]pentyl]urea	IK-950	Mus musculus
1-adamantyl-3-cyclohexylurea	-	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
lung	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(5Z,8Z,14Z)-11,12-epoxyeicosa-5,8,14-trienoic acid + H2O	i.e. 11,12-EET	Mus musculus	(5Z,8Z,14Z)-11,12-dihydroxyeicosa-5,8,14-trienoic acid	i.e. 11,12-DHET	?

Synonyms

Synonyms	Comment	Organism
SEH	-	Mus musculus

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Release 2023.1 (January 2023)