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Literature summary for 3.3.2.10 extracted from

  • Liu, J.Y.; Tsai, H.J.; Hwang, S.H.; Jones, P.D.; Morisseau, C.; Hammock, B.D.
    Pharmacokinetic optimization of four soluble epoxide hydrolase inhibitors for use in a murine model of inflammation (2009), Br. J. Pharmacol., 156, 284-296.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.3.2.10

Inhibitors

Inhibitors Comment Organism Structure
1-trifluoromethoxyphenyl-3-(1-acetylpiperidin-4-yl)urea
-
 Homo sapiens
1-trifluoromethoxyphenyl-3-(1-acetylpiperidin-4-yl)urea
-
 Mus musculus
1-trifluoromethoxyphenyl-3-(1-acetylpiperidin-4-yl)urea
-
 Rattus norvegicus
12-(3-adamantan-1-yl-ureido)-dodecanoic acid
-
 Homo sapiens
12-(3-adamantan-1-yl-ureido)-dodecanoic acid
-
 Mus musculus
12-(3-adamantan-1-yl-ureido)-dodecanoic acid
-
 Rattus norvegicus
12-(3-adamantan-1-ylureido)dodecanoic acid
-
 Homo sapiens
12-(3-adamantan-1-ylureido)dodecanoic acid
-
 Mus musculus
12-(3-adamantan-1-ylureido)dodecanoic acid
-
 Rattus norvegicus
12-(3-adamantan-1-ylureido)dodecanoic acid butyl ester
-
 Homo sapiens
12-(3-adamantan-1-ylureido)dodecanoic acid butyl ester
-
 Mus musculus
12-(3-adamantan-1-ylureido)dodecanoic acid butyl ester
-
 Rattus norvegicus
cis-4-[4-(3-adamantan-1-yl-ureido)cyclohexyloxy]benzoic acid
-
 Homo sapiens
cis-4-[4-(3-adamantan-1-yl-ureido)cyclohexyloxy]benzoic acid
-
 Mus musculus
cis-4-[4-(3-adamantan-1-yl-ureido)cyclohexyloxy]benzoic acid
-
 Rattus norvegicus
N-(1-acetylpiperidin-4-yl)-N'-(adamant-1-yl)urea
-
 Homo sapiens
N-(1-acetylpiperidin-4-yl)-N'-(adamant-1-yl)urea
-
 Mus musculus
N-(1-acetylpiperidin-4-yl)-N'-(adamant-1-yl)urea
-
 Rattus norvegicus
trans-4-[4-(3-adamantan-1-yl-ureido)cyclohexyloxy]benzoic acid potent sEH inhibitor Homo sapiens
trans-4-[4-(3-adamantan-1-yl-ureido)cyclohexyloxy]benzoic acid potent sEH inhibitor Mus musculus
trans-4-[4-(3-adamantan-1-yl-ureido)cyclohexyloxy]benzoic acid potent sEH inhibitor Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cyano(2-methoxynaphthalen-6-yl)methyl(3-phenyloxiran-2-yl)methyl carbonate + H2O
-
 Rattus norvegicus ?
-
 ?
cyano(6-methoxynaphthalen-2-yl)methyl (3-phenyloxiran-2-yl)acetate + H2O
-
 Mus musculus [1,2-dihydroxy-2-(3-phenyloxiran-2-yl)ethoxy](6-methoxynaphthalen-2-yl)acetonitrile
-
 ?
cyano(6-methoxynaphthalen-2-yl)methyl (3-phenyloxiran-2-yl)acetate + H2O
-
 Homo sapiens [1,2-dihydroxy-2-(3-phenyloxiran-2-yl)ethoxy](6-methoxynaphthalen-2-yl)acetonitrile
-
 ?

Synonyms

Synonyms Comment Organism
SEH
-
 Mus musculus
SEH
-
 Homo sapiens
SEH
-
 Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000008
-
 in bis-Tris/HCl buffer, pH 7.0, at 25°C Homo sapiens 12-(3-adamantan-1-ylureido)dodecanoic acid butyl ester
0.0000009
-
 in bis-Tris/HCl buffer, pH 7.0, at 25°C Homo sapiens cis-4-[4-(3-adamantan-1-yl-ureido)cyclohexyloxy]benzoic acid
0.0000013
-
 in bis-Tris/HCl buffer, pH 7.0, at 25°C Homo sapiens trans-4-[4-(3-adamantan-1-yl-ureido)cyclohexyloxy]benzoic acid
0.000003
-
 in bis-Tris/HCl buffer, pH 7.0, at 25°C Homo sapiens 12-(3-adamantan-1-ylureido)dodecanoic acid
0.000004
-
 in bis-Tris/HCl buffer, pH 7.0, at 25°C Mus musculus cis-4-[4-(3-adamantan-1-yl-ureido)cyclohexyloxy]benzoic acid
0.000004
-
 in bis-Tris/HCl buffer, pH 7.0, at 25°C Mus musculus 12-(3-adamantan-1-ylureido)dodecanoic acid butyl ester
0.000005
-
 in bis-Tris/HCl buffer, pH 7.0, at 25°C Rattus norvegicus 12-(3-adamantan-1-ylureido)dodecanoic acid butyl ester
0.000006
-
 in bis-Tris/HCl buffer, pH 7.0, at 25°C Rattus norvegicus N-(1-acetylpiperidin-4-yl)-N'-(adamant-1-yl)urea
0.000007
-
 in bis-Tris/HCl buffer, pH 7.0, at 25°C Homo sapiens N-(1-acetylpiperidin-4-yl)-N'-(adamant-1-yl)urea
0.000007
-
 in bis-Tris/HCl buffer, pH 7.0, at 25°C Rattus norvegicus cis-4-[4-(3-adamantan-1-yl-ureido)cyclohexyloxy]benzoic acid
0.000008
-
 in bis-Tris/HCl buffer, pH 7.0, at 25°C Mus musculus trans-4-[4-(3-adamantan-1-yl-ureido)cyclohexyloxy]benzoic acid
0.000008
-
 in bis-Tris/HCl buffer, pH 7.0, at 25°C Rattus norvegicus trans-4-[4-(3-adamantan-1-yl-ureido)cyclohexyloxy]benzoic acid
0.000009
-
 in bis-Tris/HCl buffer, pH 7.0, at 25°C Mus musculus N-(1-acetylpiperidin-4-yl)-N'-(adamant-1-yl)urea
0.00001
-
 in bis-Tris/HCl buffer, pH 7.0, at 25°C Mus musculus 12-(3-adamantan-1-ylureido)dodecanoic acid
0.000011
-
 in bis-Tris/HCl buffer, pH 7.0, at 25°C Rattus norvegicus 12-(3-adamantan-1-ylureido)dodecanoic acid
0.000012
-
 in bis-Tris/HCl buffer, pH 7.0, at 25°C Homo sapiens 1-trifluoromethoxyphenyl-3-(1-acetylpiperidin-4-yl)urea
0.000079
-
 in bis-Tris/HCl buffer, pH 7.0, at 25°C Rattus norvegicus 1-trifluoromethoxyphenyl-3-(1-acetylpiperidin-4-yl)urea
0.000097
-
 in bis-Tris/HCl buffer, pH 7.0, at 25°C Mus musculus 1-trifluoromethoxyphenyl-3-(1-acetylpiperidin-4-yl)urea