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Literature summary for 3.3.2.10 extracted from

  • Tran, K.L.; Aronov, P.A.; Tanaka, H.; Newman, J.W.; Hammock, B.D.; Morisseau, C.
    Lipid sulfates and sulfonates are allosteric competitive inhibitors of the N-terminal phosphatase activity of the mammalian soluble poxide hydrolase (2005), Biochemistry, 44, 12179-12187.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.3.2.10

Inhibitors

Inhibitors Comment Organism Structure
10-(sulfooxy)octadecanoic acid IC50 is 0.028 mM Homo sapiens
12-sulfonoxy-cis-9-octadecenoic acid IC50 is above 0.1 mM Homo sapiens
12-sulfonoxy-trans-9-octadecenoic acid IC50 is 0.016 mM Homo sapiens
4-nitrophenyl sulfate IC50 is above 0.1 mM Homo sapiens
9-hydroxy-10-(sulfooxy)octadecanoic acid IC50 is 0.09 mM Homo sapiens
alpha-hydroxyfarnesyl phosphonic acid IC50 is 0.073 mM Homo sapiens
alpha-sulfostearic acid IC50 is above 0.1 mM Homo sapiens
D-galactose 6-sulfate IC50 is above 0.1 mM Homo sapiens
dibenzyl phosphonate IC50 is above 0.1 mM Homo sapiens
diethyl 2,2,2-trifluoro-1-hydroxyethyl phosphonate IC50 is above 0.1 mM Homo sapiens
diethyl 4-methylbenzyl phosphonate IC50 is above 0.1 mM Homo sapiens
diethyl allyl phosphonate IC50 is above 0.1 mM Homo sapiens
diethyl benzoylphosphonate IC50 is above 0.1 mM Homo sapiens
diethyl cyclopropyl methylphosphonate IC50 is above 0.1 mM Homo sapiens
diethyl ethylthiomethyl phosphonate IC50 is above 0.1 mM Homo sapiens
diethyl trans-cinnamyl phosphonate IC50 is above 0.1 mM Homo sapiens
diethyl vinylphosphonate IC50 is above 0.1 mM Homo sapiens
dimethyl 2-oxoheptyl phosphonate IC50 is above 0.1 mM Homo sapiens
dioctyl phenyl phosphonate IC50 is 0.092 mM Homo sapiens
dodecyl phosphonic acid IC50 is 0.040 mM Homo sapiens
Estrone 3-sulfate IC50 is above 0.1 mM Homo sapiens
L-ascorbic acid 2-sulfate IC50 is above 0.1 mM Homo sapiens
additional information inhibition mechanism of sulfates, sulfonates, and phosphonates Homo sapiens
N-acetyl-D-galactosamine 4-sulfate IC50 is above 0.1 mM Homo sapiens
octadecan-9-yl sulfate IC50 is 0.021 mM Homo sapiens
Sodium dodecyl sulfate IC50 is above 0.1 mM Homo sapiens
sodium dodecyl sulfonate IC50 is 0.05 mM Homo sapiens
taurocholic acid IC50 is 0.09 mM Homo sapiens
taurolithocholic acid 3-sulfate IC50 is above 0.1 mM Homo sapiens
tetraisopropyl methylenediphosphonate IC50 is above 0.1 mM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
an epoxide + H2O = a glycol the C-terminal part harbors the epoxide hydrolase activity, the phosphatase activity of the enzyme is located at the N-terminal part of EC 3.1.3.76, both catalytic sites act independently Homo sapiens
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl-trans-2,3-epoxy-3-phenylpropyl carbonate + H2O
-
 Homo sapiens ?
-
 ?
racemic trans-1,3-diphenylpropene oxide + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Cterm-EH
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.016
-
 IC50 is 0.016 mM Homo sapiens 12-sulfonoxy-trans-9-octadecenoic acid
0.021
-
 IC50 is 0.021 mM Homo sapiens octadecan-9-yl sulfate
0.028
-
 IC50 is 0.028 mM Homo sapiens 10-(sulfooxy)octadecanoic acid
0.04
-
 IC50 is 0.040 mM Homo sapiens dodecyl phosphonic acid
0.05
-
 IC50 is 0.05 mM Homo sapiens sodium dodecyl sulfonate
0.073
-
 IC50 is 0.073 mM Homo sapiens alpha-hydroxyfarnesyl phosphonic acid
0.09
-
 IC50 is 0.09 mM Homo sapiens taurocholic acid
0.09
-
 IC50 is 0.09 mM Homo sapiens 9-hydroxy-10-(sulfooxy)octadecanoic acid
0.092
-
 IC50 is 0.092 mM Homo sapiens dioctyl phenyl phosphonate
0.1
-
 IC50 is above 0.1 mM Homo sapiens 4-nitrophenyl sulfate
0.1
-
 IC50 is above 0.1 mM Homo sapiens Sodium dodecyl sulfate
0.1
-
 IC50 is above 0.1 mM Homo sapiens Estrone 3-sulfate
0.1
-
 IC50 is above 0.1 mM Homo sapiens N-acetyl-D-galactosamine 4-sulfate
0.1
-
 IC50 is above 0.1 mM Homo sapiens alpha-sulfostearic acid
0.1
-
 IC50 is above 0.1 mM Homo sapiens taurolithocholic acid 3-sulfate
0.1
-
 IC50 is above 0.1 mM Homo sapiens D-galactose 6-sulfate
0.1
-
 IC50 is above 0.1 mM Homo sapiens L-ascorbic acid 2-sulfate
0.1
-
 IC50 is above 0.1 mM Homo sapiens tetraisopropyl methylenediphosphonate
0.1
-
 IC50 is above 0.1 mM Homo sapiens diethyl vinylphosphonate
0.1
-
 IC50 is above 0.1 mM Homo sapiens diethyl benzoylphosphonate
0.1
-
 IC50 is above 0.1 mM Homo sapiens diethyl cyclopropyl methylphosphonate
0.1
-
 IC50 is above 0.1 mM Homo sapiens diethyl trans-cinnamyl phosphonate
0.1
-
 IC50 is above 0.1 mM Homo sapiens diethyl 4-methylbenzyl phosphonate
0.1
-
 IC50 is above 0.1 mM Homo sapiens diethyl allyl phosphonate
0.1
-
 IC50 is above 0.1 mM Homo sapiens dibenzyl phosphonate
0.1
-
 IC50 is above 0.1 mM Homo sapiens dimethyl 2-oxoheptyl phosphonate
0.1
-
 IC50 is above 0.1 mM Homo sapiens diethyl 2,2,2-trifluoro-1-hydroxyethyl phosphonate
0.1
-
 IC50 is above 0.1 mM Homo sapiens diethyl ethylthiomethyl phosphonate
0.1
-
 IC50 is above 0.1 mM Homo sapiens 12-sulfonoxy-cis-9-octadecenoic acid