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Literature summary for 3.3.2.10 extracted from
- Enzymic conversion of 11,12-leukotriene A4 to 11,12-dihydroxy-5,14-cis-7,9-trans-eicosatetraenoic acid. Purification of an epoxide hydrolase from the guinea pig liver cytosol (1989), J. Biol. Chem., 264, 5799-5805.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Chalcone oxide | inhibits hydration of (11S,12S)-epoxy-5,14-cis-7,9-trans-eicosatetraenoic acid | Cavia porcellus |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.018 | - |
(11S,12S)-Epoxy-5,14-cis-7,9-trans-eicosatetraenoic acid | - |
Cavia porcellus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Cavia porcellus | 5829 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 60000 | - |
x * 60000, SDS-PAGE | Cavia porcellus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cavia porcellus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Cavia porcellus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adrenal gland | - |
Cavia porcellus | - |
| brain | - |
Cavia porcellus | - |
| liver | - |
Cavia porcellus | - |
| small intestine | - |
Cavia porcellus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (11S,12S)-epoxy-5,14-cis-7,9-trans-eicosatetraenoic acid + H2O | i.e. 11,12-leukotriene A4 | Cavia porcellus | (11R,12S)-dihydroxy-5,14-cis-7,9-trans-eicosatetraenoic acid + H2O | - |
? | |
| 14,15-leukotriene A4 + H2O | - |
Cavia porcellus | ? | - |
? | |
| cis-stilbene oxide + H2O | - |
Cavia porcellus | ? | - |
? | |
| leukotriene A4 + H2O | - |
Cavia porcellus | ? | - |
? | |
| styrene oxide + H2O | - |
Cavia porcellus | styrene glycol | - |
? | |
| trans-2-methylstyrene oxide + H2O | - |
Cavia porcellus | ? | - |
? | |
| trans-beta-methylstyrene oxide + H2O | - |
Cavia porcellus | ? | - |
? | |
| trans-ethyl styrene oxide + H2O | - |
Cavia porcellus | ? | - |
? | |
| trans-stilbene oxide + H2O | - |
Cavia porcellus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 60000, SDS-PAGE | Cavia porcellus |
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