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Literature summary for 3.3.2.1 extracted from

  • Hubrich, F.; Mordhorst, S.; Andexer, J.N.
    Cinnamic acid derivatives as inhibitors for chorismatases and isochorismatases (2013), Bioorg. Med. Chem. Lett., 23, 1477-1481.
    View publication on PubMed
Search for more literature for 3.3.2.1

Inhibitors

Inhibitors Comment Organism Structure
disodium 3-(2-carboxylatoethyl)benzoate
-
 Escherichia coli
disodium 3-[(E)-2-carboxylatoethenyl]benzoate
-
 Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
isochorismate + H2O Escherichia coli
-
 (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
isochorismate + H2O
-
 Escherichia coli (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate
-
 ?

Synonyms

Synonyms Comment Organism
EntB
-
 Escherichia coli

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.122
-
 disodium 3-[(E)-2-carboxylatoethenyl]benzoate pH and temperature not specified in the publication Escherichia coli
0.282
-
 disodium 3-(2-carboxylatoethyl)benzoate pH and temperature not specified in the publication Escherichia coli

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.209
-
 pH and temperature not specified in the publication Escherichia coli disodium 3-[(E)-2-carboxylatoethenyl]benzoate
0.472
-
 pH and temperature not specified in the publication Escherichia coli disodium 3-(2-carboxylatoethyl)benzoate