Literature summary for 3.3.2.1 extracted from

Caruthers, J.; Zucker, F.; Worthey, E.; Myler, P.J.; Buckner, F.; Van Voorhuis, W.; Mehlin, C.; Boni, E.; Feist, T.; Luft, J.; Gulde, S.; Lauricella, A.; Kaluzhniy, O.; Anderson, L.; Le Trong, I.; Holmes, M.A.; Earnest, T.; Soltis, M.; Hodgson, K.O.; Hol, W.G.; Merritt, E.A.
Crystal structures and proposed structural/functional classification of three protozoan proteins from the isochorismatase superfamily (2005), Protein Sci., 14, 2887-2894.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
-	Leishmania donovani
-	Trypanosoma cruzi
-	Leishmania major

Organism

Organism	UniProt	Comment	Textmining
Leishmania donovani	-	-	-
Leishmania major	-	-	-
Trypanosoma cruzi	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
isochorismate + H2O = (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate	extended active site is formed by inter-subunit association within a tetramer	Leishmania donovani	a
isochorismate + H2O = (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate	extended active site is formed by inter-subunit association within a tetramer	Trypanosoma cruzi	a
isochorismate + H2O = (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate	extended active site is formed by inter-subunit association within a tetramer	Leishmania major	a

Subunits

Subunits	Comment	Organism
More	extended active site is formed by inter-subunit association within a tetramer	Leishmania donovani
More	extended active site is formed by inter-subunit association within a tetramer	Trypanosoma cruzi
More	extended active site is formed by inter-subunit association within a tetramer	Leishmania major

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Release 2023.1 (January 2023)