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Literature summary for 3.2.2.8 extracted from

  • Dalberto, P.; Martinelli, L.; Bachega, J.; Timmers, L.; Pinto, A.; Dadda, A.; Petersen, G.; Subtil, F.; Galina, L.; Villela, A.; Pissinate, K.; Machado, P.; Bizarro, C.; De Souza, O.; De Carvalho Filho, E.; Basso, L.; Santos, D.
    Thermodynamics, functional and structural characterization of inosine-uridine nucleoside hydrolase from Leishmania braziliensis (2017), RSC Adv., 7, 48861-48875 .
No PubMed abstract available

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Leishmania braziliensis

Crystallization (Commentary)

Crystallization (Comment) Organism
to 1.53 A resolution, orthorhombic space group I222 Leishmania braziliensis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.25
-
4-nitrophenyl beta-D-ribofuranoside pH 7.5, 25°C Leishmania braziliensis
0.5
-
Inosine pH 7.5, 25°C Leishmania braziliensis
0.6
-
adenosine pH 7.5, 25°C Leishmania braziliensis
0.7
-
cytidine pH 7.5, 25°C Leishmania braziliensis
3.6
-
uridine positive homotropic cooperativity, Hill coefficient value of 2.4, pH 7.5, 25°C Leishmania braziliensis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
136000
-
gel filtration Leishmania braziliensis

Organism

Organism UniProt Comment Textmining
Leishmania braziliensis A4H9Q9
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl beta-D-ribofuranoside + H2O
-
Leishmania braziliensis 4-nitrophenol + D-ribose
-
?
adenosine + H2O
-
Leishmania braziliensis adenine + D-ribose
-
?
cytidine + H2O
-
Leishmania braziliensis cytosine + D-ribose
-
?
guanosine + H2O
-
Leishmania braziliensis guanine + D-ribose
-
?
inosine + H2O
-
Leishmania braziliensis D-ribose + hypoxanthine
-
?
uridine + H2O
-
Leishmania braziliensis uracil + D-ribose
-
?

Subunits

Subunits Comment Organism
tetramer 4 * 34000, SDS-PAGE, 4 * 34340, calculated from sequence Leishmania braziliensis

Synonyms

Synonyms Comment Organism
LBRM_18_1610
-
Leishmania braziliensis

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.039
-
adenosine pH 7.5, 25°C Leishmania braziliensis
0.066
-
cytidine pH 7.5, 25°C Leishmania braziliensis
5.1
-
uridine pH 7.5, 25°C Leishmania braziliensis
11.2
-
Inosine pH 7.5, 25°C Leishmania braziliensis
344
-
4-nitrophenyl beta-D-ribofuranoside pH 7.5, 25°C Leishmania braziliensis

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
0.047
-
guanosine pH 7.5, 25°C Leishmania braziliensis
0.065
-
adenosine pH 7.5, 25°C Leishmania braziliensis
0.094
-
cytidine pH 7.5, 25°C Leishmania braziliensis
22
-
Inosine pH 7.5, 25°C Leishmania braziliensis
1300
-
4-nitrophenyl beta-D-ribofuranoside pH 7.5, 25°C Leishmania braziliensis