Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.2.2.8 extracted from

  • Fan, F.; Chen, N.; Wang, Y.; Wu, R.; Cao, Z.
    QM/MM and MM MD Simulations on the pyrimidine-specific nucleoside hydrolase A comprehensive understanding of enzymatic hydrolysis of uridine (2018), J. Phys. Chem. B, 122, 1121-1131 .
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
QM/MM simulations. The relatively stronger hydrogen-bond interactions between uridine and the active-site residues Gln227 and Tyr231 play an important role in enhancing the substrate binding and thus promoting the N-glycosidic bond cleavage, in comparison with inosine. The estimated energy barrier is 30 kcal/mol for the hydrolysis of inosine and 22 kcal/mol for uridine. The uridine binding is exothermic by about 23 kcal/mol, and inosine binding by 12 kcal/mol Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli C3T3U2
-
-

Synonyms

Synonyms Comment Organism
YeiK
-
Escherichia coli