Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4,6-Dihydroxy-1-beta-D-ribofuranosylpyrazolo-(3,4-d) pyrimidine | - |
Leishmania donovani | |
4-Hydroxyl-1-beta-D-ribofuranosylpyrazolo-(3,4-d) pyrimidine | - |
Leishmania donovani | |
4-Methylthio-1-beta-D-ribofuranosylpyrazolo-(3,4-d)pyrimidine | - |
Leishmania donovani | |
4-Thio-1-beta-D-ribofuranosylpyrazolo-(3,4-d)pyrimidine | - |
Leishmania donovani | |
adenosine | - |
Leishmania donovani | |
guanosine | - |
Leishmania donovani | |
additional information | poor inhibitors | Leishmania donovani |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.33 | - |
6-mercaptopurine ribonucleoside | - |
Leishmania donovani | |
0.62 | - |
Inosine | - |
Leishmania donovani | |
0.78 | - |
purine ribonucleoside | - |
Leishmania donovani | |
1.06 | - |
uridine | - |
Leishmania donovani | |
1.11 | - |
Xanthosine | - |
Leishmania donovani | |
5.5 | - |
uridine | - |
Leishmania donovani |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
180000 | - |
gel filtration | Leishmania donovani |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-D-ribosylpyrimidine | Leishmania donovani | - |
pyrimidine + D-ribose | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Leishmania donovani | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Leishmania donovani |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
promastigote | - |
Leishmania donovani | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
8.5 | - |
substrate: uridine | Leishmania donovani |
Storage Stability | Organism |
---|---|
3°C, cell extract heated for 10 min at 55°C before passage through a DEAE-cellulose column, enzyme thus purified loses 5% of activity after 30 days | Leishmania donovani |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
6-mercaptopurine ribonucleoside + H2O | - |
Leishmania donovani | 6-mercaptopurine + D-ribose | - |
? | |
cytidine + H2O | - |
Leishmania donovani | cytosine + D-ribose | - |
? | |
inosine + H2O | - |
Leishmania donovani | hypoxanthine + D-ribose | - |
? | |
additional information | not: adenosine and guanosine | Leishmania donovani | ? | - |
? | |
N-D-ribosylpyrimidine | - |
Leishmania donovani | pyrimidine + D-ribose | - |
? | |
N-D-ribosylpyrimidine + H2O | - |
Leishmania donovani | pyrimidine + D-ribose | - |
? | |
purine D-ribonucleosides + H2O | appreciable substrate activity if a hydroxyl or thio group is present in the 6-position or if a hydroxyl group is present in the 2- and 6-position, preference for oxo versus amino substituents | Leishmania donovani | purine + D-ribose | - |
? | |
purine D-ribonucleosides + H2O | prefers pyrimidines | Leishmania donovani | purine + D-ribose | - |
? | |
uridine + H2O | cleaves uridine most efficiantly | Leishmania donovani | uracil + D-ribose | - |
? | |
xanthosine + H2O | - |
Leishmania donovani | xanthine + D-ribose | - |
? |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
55 | - |
after 2 min: all of the uridine-cleaving activity and 62% of the inosine-cleaving activity remains | Leishmania donovani |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.5 | - |
substrate: uridine | Leishmania donovani |