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Literature summary for 3.2.2.6 extracted from

  • Shrimp, J.H.; Hu, J.; Dong, M.; Wang, B.S.; MacDonald, R.; Jiang, H.; Hao, Q.; Yen, A.; Lin, H.
    Revealing CD38 cellular localization using a cell permeable, mechanism-based fluorescent small-molecule probe (2014), J. Am. Chem. Soc., 136, 5656-5663.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.2.2.6

Protein Variants

Protein Variants Comment Organism
E226D site-directed mutagenesis, inactive catalytic site mutant Homo sapiens
E226Q site-directed mutagenesis, inactive catalytic site mutant Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane CD38 is a type II transmembrane protein Homo sapiens 16020
-
plasma membrane CD38 is predominately on the plasma membrane of Raji and retinoic acid-treated HL-60 cells Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cyclic ADP-ribose + H2O Homo sapiens
-
 ADP-D-ribose
-
 ?
NAD+ Homo sapiens
-
 cyclic ADP-ribose + nicotinamide
-
 ?
NAD+ + H2O Homo sapiens overall reaction ADP-D-ribose + nicotinamide
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P28907
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HL-60 cell the enzymeis induced by retinoic acid, no activity in untreated cells Homo sapiens
-
additional information no enzyme expression in K-562 cells Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cyclic ADP-ribose + H2O
-
 Homo sapiens ADP-D-ribose
-
 ?
NAD+
-
 Homo sapiens cyclic ADP-ribose + nicotinamide
-
 ?
NAD+ + H2O overall reaction Homo sapiens ADP-D-ribose + nicotinamide
-
 ?

Synonyms

Synonyms Comment Organism
CD38
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens

Expression

Organism Comment Expression
Homo sapiens enzyme induction by retinoic acid in HL-60 cells up

General Information

General Information Comment Organism
physiological function CD38 is an NAD+-metabolizing enzyme in mammals, a type II transmembrane protein that converts NAD+ primarily to adenosine diphosphate ribose and a small amount of cyclic adenosine diphosphate ribose. The major enzymatic function of the enzyme is to hydrolyze extracellular rather than intracellular NAD+ Homo sapiens