BRENDA - Enzyme Database
show all sequences of 3.2.2.6

Catalysis-based inhibitors of the calcium signaling function of CD38

Kwong, A.; Chen, Z.; Zhang, H.; Leung, F.; Lam, C.; Ting, K.; Zhang, L.; Hao, Q.; Zhang, L.; Lee, H.; Biochemistry 51, 555-564 (2012)

Data extracted from this reference:

Crystallization (Commentary)
Crystallization
Organism
enzyme in complex with inhibitors, hanging drop vapor diffusion method, mixing of 10 mg/ml protein in 20 mM HEPES with 5 mm ligands, with reservoir solution containing 0.1 M sodium acetate, pH 4.0, 0.2 M ammonium acetate, 3% 2-propanol, and 15% PEG 10000, X-ray diffraction structure determination and analysis, molecular replacement
Mus musculus
Inhibitors
Inhibitors
Commentary
Organism
Structure
1-[2-azido-2-deoxy-5-O-phosphono-D-threo-pentofuranosyl]-3-carbamoylpyridinium
inhibition of the NADase activity
Homo sapiens
1-[2-azido-2-deoxy-5-O-phosphono-D-threo-pentofuranosyl]-3-carbamoylpyridinium
inhibition of the NADase activity
Mus musculus
1-[2-azido-2-deoxy-5-O-phosphono-D-threo-pentofuranosyl]-3-carbamoylpyridinium
inhibition of the NADase activity
Rattus norvegicus
1-[5-O-[(benzyloxy)(hydroxy)phosphoryl]-2-deoxy-2-fluoro-L-erythro-pentofuranosyl]-3-carbamoylpyridinium
inhibition of the NADase activity
Homo sapiens
1-[5-O-[(benzyloxy)(hydroxy)phosphoryl]-2-deoxy-2-fluoro-L-erythro-pentofuranosyl]-3-carbamoylpyridinium
inhibition of the NADase activity
Mus musculus
1-[5-O-[(benzyloxy)(hydroxy)phosphoryl]-2-deoxy-2-fluoro-L-erythro-pentofuranosyl]-3-carbamoylpyridinium
inhibition of the NADase activity
Rattus norvegicus
1-[5-O-[butoxy(hydroxy)phosphoryl]-2-deoxy-2-fluoro-D-threo-pentofuranosyl]-3-carbamoylpyridinium
inhibition of the NADase activity
Homo sapiens
1-[5-O-[butoxy(hydroxy)phosphoryl]-2-deoxy-2-fluoro-D-threo-pentofuranosyl]-3-carbamoylpyridinium
inhibition of the NADase activity
Mus musculus
1-[5-O-[butoxy(hydroxy)phosphoryl]-2-deoxy-2-fluoro-D-threo-pentofuranosyl]-3-carbamoylpyridinium
inhibition of the NADase activity
Rattus norvegicus
3-carbamoyl-1-[2-chloro-2-deoxy-5-O-phosphono-D-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
Homo sapiens
3-carbamoyl-1-[2-chloro-2-deoxy-5-O-phosphono-D-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
Mus musculus
3-carbamoyl-1-[2-chloro-2-deoxy-5-O-phosphono-D-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
Rattus norvegicus
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-phosphono-D-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
Homo sapiens
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-phosphono-D-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
Mus musculus
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-phosphono-D-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
Rattus norvegicus
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-phosphono-L-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
Homo sapiens
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-phosphono-L-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
Mus musculus
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-phosphono-L-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
Rattus norvegicus
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-thiophosphono-L-erythro-pentofuranosyl]pyridinium
inhibition of the NADase activity
Homo sapiens
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-thiophosphono-L-erythro-pentofuranosyl]pyridinium
inhibition of the NADase activity
Mus musculus
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-thiophosphono-L-erythro-pentofuranosyl]pyridinium
inhibition of the NADase activity
Rattus norvegicus
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-[(hexyloxy)(hydroxy)phosphoryl]-D-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
Homo sapiens
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-[(hexyloxy)(hydroxy)phosphoryl]-D-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
Mus musculus
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-[(hexyloxy)(hydroxy)phosphoryl]-D-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
Rattus norvegicus
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-[hydroxy(2-phenylethoxy)phosphoryl]-L-erythro-pentofuranosyl]pyridinium
inhibition of the NADase activity
Homo sapiens
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-[hydroxy(2-phenylethoxy)phosphoryl]-L-erythro-pentofuranosyl]pyridinium
inhibition of the NADase activity
Mus musculus
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-[hydroxy(2-phenylethoxy)phosphoryl]-L-erythro-pentofuranosyl]pyridinium
inhibition of the NADase activity
Rattus norvegicus
3-carbamoyl-1-[2-deoxy-2-fluoro-D-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
Homo sapiens
3-carbamoyl-1-[2-deoxy-2-fluoro-D-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
Mus musculus
3-carbamoyl-1-[2-deoxy-2-fluoro-D-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
Rattus norvegicus
3-carbamoyl-1-[2-deoxy-5-O-(diethoxyphosphoryl)-2-fluoro-D-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
Homo sapiens
3-carbamoyl-1-[2-deoxy-5-O-(diethoxyphosphoryl)-2-fluoro-D-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
Mus musculus
3-carbamoyl-1-[2-deoxy-5-O-(diethoxyphosphoryl)-2-fluoro-D-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
Rattus norvegicus
3-carbamoyl-1-[2-deoxy-5-O-[(ethenyloxy)(propoxy)phosphoryl]-2-fluoro-D-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
Homo sapiens
3-carbamoyl-1-[2-deoxy-5-O-[(ethenyloxy)(propoxy)phosphoryl]-2-fluoro-D-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
Mus musculus
3-carbamoyl-1-[2-deoxy-5-O-[(ethenyloxy)(propoxy)phosphoryl]-2-fluoro-D-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
Rattus norvegicus
3-carbamoyl-1-[3-deoxy-3-fluoro-5-O-phosphono-L-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
Homo sapiens
3-carbamoyl-1-[3-deoxy-3-fluoro-5-O-phosphono-L-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
Mus musculus
3-carbamoyl-1-[3-deoxy-3-fluoro-5-O-phosphono-L-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
Rattus norvegicus
arabinosyl-2'-fluoro-2'-deoxynicotinamide mononucleotide
inhibition of the NADase activity
Homo sapiens
arabinosyl-2'-fluoro-2'-deoxynicotinamide mononucleotide
inhibition of the NADase activity
Mus musculus
arabinosyl-2'-fluoro-2'-deoxynicotinamide mononucleotide
inhibition of the NADase activity
Rattus norvegicus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
cyclic ADP-ribose + H2O
Rattus norvegicus
-
ADP-D-ribose
-
-
?
cyclic ADP-ribose + H2O
Homo sapiens
-
ADP-D-ribose
-
-
?
cyclic ADP-ribose + H2O
Mus musculus
-
ADP-D-ribose
-
-
?
NAD+
Rattus norvegicus
-
cyclic ADP-ribose + nicotinamide
-
-
?
NAD+
Homo sapiens
-
cyclic ADP-ribose + nicotinamide
-
-
?
NAD+
Mus musculus
-
cyclic ADP-ribose + nicotinamide
-
-
?
NAD+ + H2O
Rattus norvegicus
overall reaction
ADP-D-ribose + nicotinamide
-
-
?
NAD+ + H2O
Homo sapiens
overall reaction
ADP-D-ribose + nicotinamide
-
-
?
NAD+ + H2O
Mus musculus
overall reaction
ADP-D-ribose + nicotinamide
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
P28907
-
-
Mus musculus
P56528
-
-
Rattus norvegicus
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
brain
-
Mus musculus
-
HL-60 cell
-
Homo sapiens
-
mesenteric artery
-
Rattus norvegicus
-
ventricular zone
-
Rattus norvegicus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
cyclic ADP-ribose + H2O
-
731296
Rattus norvegicus
ADP-D-ribose
-
-
-
?
cyclic ADP-ribose + H2O
-
731296
Homo sapiens
ADP-D-ribose
-
-
-
?
cyclic ADP-ribose + H2O
-
731296
Mus musculus
ADP-D-ribose
-
-
-
?
NAD+
-
731296
Rattus norvegicus
cyclic ADP-ribose + nicotinamide
-
-
-
?
NAD+
-
731296
Homo sapiens
cyclic ADP-ribose + nicotinamide
-
-
-
?
NAD+
-
731296
Mus musculus
cyclic ADP-ribose + nicotinamide
-
-
-
?
NAD+ + H2O
overall reaction
731296
Rattus norvegicus
ADP-D-ribose + nicotinamide
-
-
-
?
NAD+ + H2O
overall reaction
731296
Homo sapiens
ADP-D-ribose + nicotinamide
-
-
-
?
NAD+ + H2O
overall reaction
731296
Mus musculus
ADP-D-ribose + nicotinamide
-
-
-
?
Temperature Optimum [C]
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
37
-
assay at
Homo sapiens
37
-
assay at
Mus musculus
37
-
assay at
Rattus norvegicus
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.4
-
assay at
Homo sapiens
7.4
-
assay at
Mus musculus
7.4
-
assay at
Rattus norvegicus
Crystallization (Commentary) (protein specific)
Crystallization
Organism
enzyme in complex with inhibitors, hanging drop vapor diffusion method, mixing of 10 mg/ml protein in 20 mM HEPES with 5 mm ligands, with reservoir solution containing 0.1 M sodium acetate, pH 4.0, 0.2 M ammonium acetate, 3% 2-propanol, and 15% PEG 10000, X-ray diffraction structure determination and analysis, molecular replacement
Mus musculus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
1-[2-azido-2-deoxy-5-O-phosphono-D-threo-pentofuranosyl]-3-carbamoylpyridinium
inhibition of the NADase activity
Homo sapiens
1-[2-azido-2-deoxy-5-O-phosphono-D-threo-pentofuranosyl]-3-carbamoylpyridinium
inhibition of the NADase activity
Mus musculus
1-[2-azido-2-deoxy-5-O-phosphono-D-threo-pentofuranosyl]-3-carbamoylpyridinium
inhibition of the NADase activity
Rattus norvegicus
1-[5-O-[(benzyloxy)(hydroxy)phosphoryl]-2-deoxy-2-fluoro-L-erythro-pentofuranosyl]-3-carbamoylpyridinium
inhibition of the NADase activity
Homo sapiens
1-[5-O-[(benzyloxy)(hydroxy)phosphoryl]-2-deoxy-2-fluoro-L-erythro-pentofuranosyl]-3-carbamoylpyridinium
inhibition of the NADase activity
Mus musculus
1-[5-O-[(benzyloxy)(hydroxy)phosphoryl]-2-deoxy-2-fluoro-L-erythro-pentofuranosyl]-3-carbamoylpyridinium
inhibition of the NADase activity
Rattus norvegicus
1-[5-O-[butoxy(hydroxy)phosphoryl]-2-deoxy-2-fluoro-D-threo-pentofuranosyl]-3-carbamoylpyridinium
inhibition of the NADase activity
Homo sapiens
1-[5-O-[butoxy(hydroxy)phosphoryl]-2-deoxy-2-fluoro-D-threo-pentofuranosyl]-3-carbamoylpyridinium
inhibition of the NADase activity
Mus musculus
1-[5-O-[butoxy(hydroxy)phosphoryl]-2-deoxy-2-fluoro-D-threo-pentofuranosyl]-3-carbamoylpyridinium
inhibition of the NADase activity
Rattus norvegicus
3-carbamoyl-1-[2-chloro-2-deoxy-5-O-phosphono-D-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
Homo sapiens
3-carbamoyl-1-[2-chloro-2-deoxy-5-O-phosphono-D-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
Mus musculus
3-carbamoyl-1-[2-chloro-2-deoxy-5-O-phosphono-D-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
Rattus norvegicus
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-phosphono-D-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
Homo sapiens
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-phosphono-D-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
Mus musculus
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-phosphono-D-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
Rattus norvegicus
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-phosphono-L-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
Homo sapiens
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-phosphono-L-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
Mus musculus
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-phosphono-L-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
Rattus norvegicus
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-thiophosphono-L-erythro-pentofuranosyl]pyridinium
inhibition of the NADase activity
Homo sapiens
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-thiophosphono-L-erythro-pentofuranosyl]pyridinium
inhibition of the NADase activity
Mus musculus
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-thiophosphono-L-erythro-pentofuranosyl]pyridinium
inhibition of the NADase activity
Rattus norvegicus
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-[(hexyloxy)(hydroxy)phosphoryl]-D-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
Homo sapiens
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-[(hexyloxy)(hydroxy)phosphoryl]-D-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
Mus musculus
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-[(hexyloxy)(hydroxy)phosphoryl]-D-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
Rattus norvegicus
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-[hydroxy(2-phenylethoxy)phosphoryl]-L-erythro-pentofuranosyl]pyridinium
inhibition of the NADase activity
Homo sapiens
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-[hydroxy(2-phenylethoxy)phosphoryl]-L-erythro-pentofuranosyl]pyridinium
inhibition of the NADase activity
Mus musculus
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-[hydroxy(2-phenylethoxy)phosphoryl]-L-erythro-pentofuranosyl]pyridinium
inhibition of the NADase activity
Rattus norvegicus
3-carbamoyl-1-[2-deoxy-2-fluoro-D-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
Homo sapiens
3-carbamoyl-1-[2-deoxy-2-fluoro-D-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
Mus musculus
3-carbamoyl-1-[2-deoxy-2-fluoro-D-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
Rattus norvegicus
3-carbamoyl-1-[2-deoxy-5-O-(diethoxyphosphoryl)-2-fluoro-D-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
Homo sapiens
3-carbamoyl-1-[2-deoxy-5-O-(diethoxyphosphoryl)-2-fluoro-D-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
Mus musculus
3-carbamoyl-1-[2-deoxy-5-O-(diethoxyphosphoryl)-2-fluoro-D-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
Rattus norvegicus
3-carbamoyl-1-[2-deoxy-5-O-[(ethenyloxy)(propoxy)phosphoryl]-2-fluoro-D-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
Homo sapiens
3-carbamoyl-1-[2-deoxy-5-O-[(ethenyloxy)(propoxy)phosphoryl]-2-fluoro-D-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
Mus musculus
3-carbamoyl-1-[2-deoxy-5-O-[(ethenyloxy)(propoxy)phosphoryl]-2-fluoro-D-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
Rattus norvegicus
3-carbamoyl-1-[3-deoxy-3-fluoro-5-O-phosphono-L-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
Homo sapiens
3-carbamoyl-1-[3-deoxy-3-fluoro-5-O-phosphono-L-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
Mus musculus
3-carbamoyl-1-[3-deoxy-3-fluoro-5-O-phosphono-L-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
Rattus norvegicus
arabinosyl-2'-fluoro-2'-deoxynicotinamide mononucleotide
inhibition of the NADase activity
Homo sapiens
arabinosyl-2'-fluoro-2'-deoxynicotinamide mononucleotide
inhibition of the NADase activity
Mus musculus
arabinosyl-2'-fluoro-2'-deoxynicotinamide mononucleotide
inhibition of the NADase activity
Rattus norvegicus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
cyclic ADP-ribose + H2O
Rattus norvegicus
-
ADP-D-ribose
-
-
?
cyclic ADP-ribose + H2O
Homo sapiens
-
ADP-D-ribose
-
-
?
cyclic ADP-ribose + H2O
Mus musculus
-
ADP-D-ribose
-
-
?
NAD+
Rattus norvegicus
-
cyclic ADP-ribose + nicotinamide
-
-
?
NAD+
Homo sapiens
-
cyclic ADP-ribose + nicotinamide
-
-
?
NAD+
Mus musculus
-
cyclic ADP-ribose + nicotinamide
-
-
?
NAD+ + H2O
Rattus norvegicus
overall reaction
ADP-D-ribose + nicotinamide
-
-
?
NAD+ + H2O
Homo sapiens
overall reaction
ADP-D-ribose + nicotinamide
-
-
?
NAD+ + H2O
Mus musculus
overall reaction
ADP-D-ribose + nicotinamide
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
brain
-
Mus musculus
-
HL-60 cell
-
Homo sapiens
-
mesenteric artery
-
Rattus norvegicus
-
ventricular zone
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
cyclic ADP-ribose + H2O
-
731296
Rattus norvegicus
ADP-D-ribose
-
-
-
?
cyclic ADP-ribose + H2O
-
731296
Homo sapiens
ADP-D-ribose
-
-
-
?
cyclic ADP-ribose + H2O
-
731296
Mus musculus
ADP-D-ribose
-
-
-
?
NAD+
-
731296
Rattus norvegicus
cyclic ADP-ribose + nicotinamide
-
-
-
?
NAD+
-
731296
Homo sapiens
cyclic ADP-ribose + nicotinamide
-
-
-
?
NAD+
-
731296
Mus musculus
cyclic ADP-ribose + nicotinamide
-
-
-
?
NAD+ + H2O
overall reaction
731296
Rattus norvegicus
ADP-D-ribose + nicotinamide
-
-
-
?
NAD+ + H2O
overall reaction
731296
Homo sapiens
ADP-D-ribose + nicotinamide
-
-
-
?
NAD+ + H2O
overall reaction
731296
Mus musculus
ADP-D-ribose + nicotinamide
-
-
-
?
Temperature Optimum [C] (protein specific)
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
37
-
assay at
Homo sapiens
37
-
assay at
Mus musculus
37
-
assay at
Rattus norvegicus
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.4
-
assay at
Homo sapiens
7.4
-
assay at
Mus musculus
7.4
-
assay at
Rattus norvegicus
General Information
General Information
Commentary
Organism
malfunction
ablation of the CD38 gene in mice causes multiple physiological defects, including impaired oxytocin release, that result in altered social behavior
Homo sapiens
malfunction
ablation of the CD38 gene in mice causes multiple physiological defects, including impaired oxytocin release, that result in altered social behavior
Mus musculus
malfunction
ablation of the CD38 gene in mice causes multiple physiological defects, including impaired oxytocin release, that result in altered social behavior
Rattus norvegicus
additional information
structure-function relationship anaysis, overview. Covalent intermediates are formed with the catalytic residue, Glu226
Homo sapiens
additional information
structure-function relationship anaysis, overview. Covalent intermediates are formed with the catalytic residue, Glu226
Mus musculus
additional information
structure-function relationship anaysis, overview. Covalent intermediates are formed with the catalytic residue, Glu226
Rattus norvegicus
physiological function
the enzyme is a signaling enzyme responsible for catalyzing the synthesis of cyclic ADP ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate, both are universal Ca2+ messenger molecules
Homo sapiens
physiological function
the enzyme is a signaling enzyme responsible for catalyzing the synthesis of cyclic ADP ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate, both are universal Ca2+ messenger molecules
Mus musculus
physiological function
the enzyme is a signaling enzyme responsible for catalyzing the synthesis of cyclic ADP ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate, both are universal Ca2+ messenger molecules
Rattus norvegicus
General Information (protein specific)
General Information
Commentary
Organism
malfunction
ablation of the CD38 gene in mice causes multiple physiological defects, including impaired oxytocin release, that result in altered social behavior
Homo sapiens
malfunction
ablation of the CD38 gene in mice causes multiple physiological defects, including impaired oxytocin release, that result in altered social behavior
Mus musculus
malfunction
ablation of the CD38 gene in mice causes multiple physiological defects, including impaired oxytocin release, that result in altered social behavior
Rattus norvegicus
additional information
structure-function relationship anaysis, overview. Covalent intermediates are formed with the catalytic residue, Glu226
Homo sapiens
additional information
structure-function relationship anaysis, overview. Covalent intermediates are formed with the catalytic residue, Glu226
Mus musculus
additional information
structure-function relationship anaysis, overview. Covalent intermediates are formed with the catalytic residue, Glu226
Rattus norvegicus
physiological function
the enzyme is a signaling enzyme responsible for catalyzing the synthesis of cyclic ADP ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate, both are universal Ca2+ messenger molecules
Homo sapiens
physiological function
the enzyme is a signaling enzyme responsible for catalyzing the synthesis of cyclic ADP ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate, both are universal Ca2+ messenger molecules
Mus musculus
physiological function
the enzyme is a signaling enzyme responsible for catalyzing the synthesis of cyclic ADP ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate, both are universal Ca2+ messenger molecules
Rattus norvegicus
Other publictions for EC 3.2.2.6
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
749830
Chini
The NADase CD38 is induced by ...
Homo sapiens
Biochem. Biophys. Res. Commun.
513
486-493
2019
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750282
Shu
Blockade of CD38 diminishes l ...
Mus musculus
Cell. Signal.
42
249-258
2018
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731357
Kuhn
Probing the catalytic mechanis ...
Bos taurus
Biochim. Biophys. Acta
1844
1317-1331
2014
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11
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12
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1
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12
731882
Ma
Basal CD38/cyclic ADP-ribose-d ...
Mus musculus
Glia
62
943-955
2014
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2
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731987
Shrimp
Revealing CD38 cellular locali ...
Homo sapiens
J. Am. Chem. Soc.
136
5656-5663
2014
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731119
Jiang
Identification of ADP-ribosyla ...
Homo sapiens
Anal. Biochem.
433
218-226
2013
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732593
Coskun
Purification of NAD+ glycohydr ...
Homo sapiens
Oncol. Lett.
6
227-231
2013
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731296
Kwong
Catalysis-based inhibitors of ...
Homo sapiens, Mus musculus, Rattus norvegicus
Biochemistry
51
555-564
2012
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1
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42
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42
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9
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732501
Ikeda
Identification of a major enzy ...
Xenopus laevis
Mol. Cell. Biochem.
366
69-80
2012
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732691
Egea
Insights into the mechanism of ...
Bos taurus
PLoS ONE
7
e34918
2012
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714434
Kellenberger
Flavonoids as inhibitors of hu ...
Homo sapiens
Bioorg. Med. Chem. Lett.
21
3939-3942
2011
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17
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714921
Congleton
ATRA-induced HL-60 myeloid leu ...
Homo sapiens
Exp. Cell Res.
317
910-919
2011
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716910
Lee
Cyclic ADP-ribose and NAADP: f ...
Mus musculus
Sci. China Life Sci.
54
699-711
2011
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326409
Orsomando
NAD(P)+-glycohydrolase from hu ...
Homo sapiens
Comp. Biochem. Physiol. B
126
89-98
2000
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2
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3
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22
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326410
Berthelier
-
Human CD38 is an authentic NAD ...
Homo sapiens
Biochem. J.
330
1383-1390
1998
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326411
Chini
Enzymatic synthesis and degrad ...
Rattus norvegicus
Biochem. Biophys. Res. Commun.
209
167-174
1995
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326406
Jorge
Carbon source regulation of ni ...
Neurospora crassa
J. Gen. Microbiol.
130
1563-1568
1984
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326403
Yamasaki
-
Purification and some properti ...
Saccharomyces cerevisiae
J. Ferment. Technol.
60
131-137
1982
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326407
Skala
Elevated NAD(P) glycohydrolase ...
Homo sapiens
Blood
60
912-917
1982
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326408
Artman
Nicotinamide adenine dinucleot ...
Oryctolagus cuniculus, Ovis aries
Can. J. Microbiol.
28
696-702
1982
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326405
Broeker
-
A nicotinamide adenine dinucle ...
Streptomyces griseus
FEMS Microbiol. Lett.
6
245-247
1979
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326404
Mather
A heat-stable nicotinamide-ade ...
Pseudomonas putida KB1
Biochem. J.
129
141-152
1972
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5
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