Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.2.2.5 extracted from

  • Chandrasekaran, S.; Caparon, M.G.
    The Streptococcus pyogenes NAD(+) glycohydrolase modulates epithelial cell PARylation and HMGB1 release (2015), Cell. Microbiol., 17, 1376-1390 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.2.2.5

Organism

Organism UniProt Comment Textmining
Streptococcus pyogenes
-
-
-
Streptococcus pyogenes JRS4
-
-
-

Synonyms

Synonyms Comment Organism
SPN
-
 Streptococcus pyogenes

General Information

General Information Comment Organism
physiological function SPN modifies several streptolysin SLO and NAD+-dependent host cell responses in patterns that correlate with NADase activity. SLO pore formation results in hyperactivation of poly-ADP-ribose polymerase-1 (PARP-1) and production of polymers of poly-ADP-ribose (PAR). SPN NADase activity moderates PARP-1 activation and blocks accumulation of PAR, these processes continued unabated in the presence of NADase-inactive SPN. PAR production is initially independent of NADase activity, but PAR rapidly disappears in the presence of NADase-active SPN, host cell ATP is depleted and the proinflammatory mediator High-Mobility Group Box-1 (HMGB1) protein is released from the nucleus by a PARP-1 dependent mechanism Streptococcus pyogenes