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Literature summary for 3.2.2.5 extracted from

  • Talluri, E.; Pancotto, L.; Ruggiero, P.; Scarselli, M.; Balducci, E.
    CagL from Helicobacter pylori has ADP-ribosylation activity and exerts partial protective efficacy in mice (2017), Arch. Biochem. Biophys., 635, 102-109 .
    View publication on PubMed
Search for more literature for 3.2.2.5

Activating Compound

Activating Compound Comment Organism Structure
additional information all the amino-acids tested Asp, Arg, Cys, His, Gln, Thr, Glu and Ser, are unable to produce enhancement of hydrolysis Helicobacter pylori

Application

Application Comment Organism
medicine vaccination with CagL has protective efficacy in mice Helicobacter pylori

Organism

Organism UniProt Comment Textmining
Helicobacter pylori
-
-
-
Helicobacter pylori Shi470
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD+ + H2O
-
 Helicobacter pylori ADP-D-ribose + nicotinamide
-
 ?
NAD+ + H2O
-
 Helicobacter pylori Shi470 ADP-D-ribose + nicotinamide
-
 ?

Synonyms

Synonyms Comment Organism
CagL
-
 Helicobacter pylori

General Information

General Information Comment Organism
physiological function CagL from Shi470 is catalytically active showing ADP-ribosyltransferase, NAD-glycohydrolase, and auto-ADP-ribosylation activities Helicobacter pylori