Literature summary for 3.2.2.5 extracted from

Hasegawa, T.; Matsumoto, M.; Hata, N.; Yano, H.; Isaka, M.; Tatsuno, I.
Homologous role of CovRS two-component regulatory system in NAD+ -glycohydrolase activity in Streptococcus dysgalactiae subsp. equisimilis as in Streptococcus pyogenes (2019), APMIS, 127, 87-92 .

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Application

Application	Comment	Organism
medicine	CovR and CovS two-component regulatory system regulates the Nga activity, which is considered important in the pathogenesis of STSS streptococcal toxic shock syndrome	Streptococcus dysgalactiae subsp. equisimilis

Organism

Organism	UniProt	Comment	Textmining
Streptococcus dysgalactiae subsp. equisimilis	-	-	-

Synonyms

Synonyms	Comment	Organism
Nga	-	Streptococcus dysgalactiae subsp. equisimilis

Expression

Organism	Comment	Expression
Streptococcus dysgalactiae subsp. equisimilis	the CovR/CovS two-component regulatory system is involved in the Nga activity. A one nucleotide mutation in the covR gene leads to 6.8fold higher Nga activity	additional information

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Release 2023.1 (January 2023)