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Literature summary for 3.2.2.5 extracted from

  • O'Seaghdha, M.; Wessels, M.R.
    Streptolysin O and its co-toxin NAD-glycohydrolase protect group A Streptococcus from xenophagic killing (2013), PLoS Pathog., 9, e1003394.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.2.2.5

Protein Variants

Protein Variants Comment Organism
G330D mutant strain 188NADase(G330D), a derivative of 188 in which the chromosomal nga locus harbors a point mutation coding for amino acid substitution G330D in NADase. This mutation causes an enzymatically inactive NADase, associated with inactive enzyme in clinical isolates of Streptococcus pyogenes and in a deliberately constructed mutant Streptococcus pyogenes

Organism

Organism UniProt Comment Textmining
Streptococcus pyogenes
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information sterptolysin O-mediated translocation of the enzyme into human host keratinocytes Streptococcus pyogenes
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Synonyms

Synonyms Comment Organism
co-toxin NADase
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 Streptococcus pyogenes
NAD-glycohydrolase
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 Streptococcus pyogenes
NADase
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 Streptococcus pyogenes

General Information

General Information Comment Organism
physiological function expression of toxin streptolysin O is associated with prolonged intracellular survival of the bacterium in human oropharyngeal keratinocytes, the predominant cell type of the pharyngeal epithelium, co-toxin NADase is required for this effect. Production of streptolysin S can mediate targeting of GAS to autophagosomes in the absence of streptolysin O, a process accompanied by galectin 8 binding to damaged Streptococcus pyogenes-containing endosomes. Maturation of Streptococcus pyogenes-containing autophagosome-like vacuoles to degradative autolysosomes is prevented by streptolysin O pore-formation and by streptolysin O-mediated translocation of enzymatically active NADase into the keratinocyte cytosol. Coordinated action of streptolysin O and NADase prevent maturation of GAS-containing autophagosomes, thereby prolonging Streptococcus pyogenes intracellular survival, overview. The activity of NADase to block autophagic killing of Streptococcus pyogenes in pharyngeal cells may contribute to pharyngitis treatment failure, relapse, and chronic carriage caused by the pathogen Streptococcus pyogenes