Cloned (Comment) | Organism |
---|---|
genotyping, SPN has a different pattern of polymorphisms than Streptococcus pyogenes housekeeping genes. The ratio of nonsynonymous to synonymous nucleotide polymorphisms reveals different patterns of evolution for NADase-active and NADase-inactive strains. SPN amino acid sequence remains preserved despite loss of NADase activity, overview | Streptococcus pyogenes |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
protein IFS | an endogenous inhibitor, encoded by gene ifs | Streptococcus pyogenes |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptococcus pyogenes | - |
diverse strains, gene spn | - |
Synonyms | Comment | Organism |
---|---|---|
NAD+ glycohydrolase | - |
Streptococcus pyogenes |
SPN | - |
Streptococcus pyogenes |
General Information | Comment | Organism |
---|---|---|
additional information | models of molecular evolution shows that SPN is evolving under positive selection and diverging into NAD+ glycohydrolase-active and -inactive subtypes | Streptococcus pyogenes |
physiological function | SPN is a virulence factor that is implicated in contributing to the pathogenesis of severe infections, e.g. of the throat, leading to pharyngitis, or the skin, leading to impetigo. NADase activity does not correlate with invasive disease, but is associated with tissue tropism. The ability to cause infection at both the pharynx and the skin is correlated with NADase-active SPN, while the preference for causing infection at either the throat or the skin is associated with NADase-inactive SPN | Streptococcus pyogenes |