Literature summary for 3.2.2.5 extracted from

Liu, Q.; Kriksunov, I.A.; Moreau, C.; Graeff, R.; Potter, B.V.; Lee, H.C.; Hao, Q.
Catalysis-associated conformational changes revealed by human CD38 complexed with a non-hydrolyzable substrate analog (2007), J. Biol. Chem., 282, 24825-24832.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
wild-type and mutant E226Q in complex with inhibitor N1-cyclic inosine diphosphate ribose at 1.7 and 1.176 A resolution, respectively	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
E226Q	crystallization data	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
N1-cyclic inosine diphosphate ribose	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P28907	isoform CD38	-

Reaction

Reaction	Comment	Organism	Reaction ID
NAD+ + H2O = ADP-D-ribose + nicotinamide + H+	residues E146, D147, and W125 work collaboratively to facilitate the formation of the Michaelis complex	Homo sapiens	a

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.26	-	pH 4.5, 20-24°C	Homo sapiens	N1-cyclic inosine diphosphate ribose

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Release 2023.1 (January 2023)