Literature summary for 3.2.2.5 extracted from

Hara-Yokoyama, M.; Kimura, T.; Kaku, H.; Wakiyama, M.; Kaitsu, Y.; Inoue, M.; Kusano, S.; Shirouzu, M.; Yokoyama, S.; Katada, T.; Hirabayashi, Y.; Takatsu, K.; Yanagishita, M.
Alteration of enzymatic properties of cell-surface antigen CD38 by agonistic anti-CD38 antibodies that prolong B cell survival and induce activation (2008), Int. Immunopharmacol., 8, 59-70.

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Activating Compound

Activating Compound	Comment	Organism	Structure
monoclonal antibody clone 90	stimulates the NAD+ glycohydrolase activity of the isolated extracellular domain of CD38, little effect on cell-surface CD38. No effect on cyclase activity of enzyme	Mus musculus

Cloned(Commentary)

Cloned (Comment)	Organism
expression of extracellular region of CD38 in Drosophila S2 cells	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
monoclonal antibody CS/2	inhibits the NAD+ glycohydolase activity of both the isolated extracellular domain of CD38 and cell-surface CD38, non-competitive. No effect on cyclase activity of enzyme	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	isoform CD38	-

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Release 2023.1 (January 2023)