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Literature summary for 3.2.2.5 extracted from

  • Ortolan, E.; Tibaldi, E.V.; Ferranti, B.; Lavagno, L.; Garbarino, G.; Notaro, R.; Luzzatto, L.; Malavasi, F.; Funaro, A.
    CD157 plays a pivotal role in neutrophil transendothelial migration (2006), Blood, 108, 4214-4222.
    View publication on PubMed
Search for more literature for 3.2.2.5

Application

Application Comment Organism
medicine CD157-deficient neutrophils from patients with paroxysmal nocturnal hemoglobinuria are characterized by a severely impaired diapedesis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens enzyme plays a crucial role in neutrophil diapedesis. Its ligation with specific monoclonal antibodies both on neutrophils or endothelial cells results in altered neutrophil movement on the apical surface of endothelium and, ultimately, in loss of diapedesis. Following CD157 ligation, neutrophils appear disoriented, meandering toward junctions where they eventually stop without transmigrating ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
HUVEC cell
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme plays a crucial role in neutrophil diapedesis. Its ligation with specific monoclonal antibodies both on neutrophils or endothelial cells results in altered neutrophil movement on the apical surface of endothelium and, ultimately, in loss of diapedesis. Following CD157 ligation, neutrophils appear disoriented, meandering toward junctions where they eventually stop without transmigrating Homo sapiens ?
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 ?

Synonyms

Synonyms Comment Organism
CD157
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 Homo sapiens