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Literature summary for 3.2.2.5 extracted from
- Nicotinamide 2-fluoroadenine dinucleotide unmasks the NAD+ glycohydrolase activity of Aplysia californica adenosine 5-diphosphate ribosyl cyclase (2007), Biochemistry, 46, 4100-4109.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0046 | - |
NAD+ | pH 7.4 | Aplysia californica |  |
| 0.016 | - |
2-fluoro-NAD+ | pH 7.4 | Aplysia californica | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Aplysia californica | - |
bifunctional adenosine 5-diphosphate ribosyl cyclase/NAD+ glycohydrolase | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-fluoro-NAD+ + H2O | in presence of methanol, formation of methanolysis product beta-1''-O-methyl 2-fluoro-ADP-ribose, with a preference for methanolysis over hydrolysis of 100:1 | Aplysia californica | 2-fluoro-ADP-ribose + nicotinamide | - |
? | |
| NAD+ + H2O | - |
Aplysia californica | ADP-ribose + nicotinamide | - |
? | |
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Release 2023.1 (January 2023)
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