Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.2.2.5 extracted from

  • Ceni, C.; Muller-Steffner, H.; Lund, F.; Pochon, N.; Schweitzer, A.; De Waard, M.; Schuber, F.; Villaz, M.; Moutin, M.J.
    Evidence for an intracellular ADP-ribosyl cyclase/NAD+-glycohydrolase in brain from CD38-deficient mice (2003), J. Biol. Chem., 278, 40670-40678.
    View publication on PubMed
Search for more literature for 3.2.2.5

Activating Compound

Activating Compound Comment Organism Structure
guanosine 5'-O-(3-thiotriphosphate) enzyme may be regulated by a G protein-dependent mechanism Mus musculus
additional information increase in activity ba Triton X-100 treatment due to solubilization from the cells Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
Zn2+ about 80% inhibition at 1 mM Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
intracellular
-
 Mus musculus 5622
-
membrane no solubilization by phosphatidylinositol-specific phospholipase C or 0.5 M KCl, but by Triton X-100 Mus musculus 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD+ + H2O Mus musculus
-
 ADP-ribose + nicotinamide
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 CD38-deficient strain, bifunctional enzyme, distinct from CD157 and CD38
-

Source Tissue

Source Tissue Comment Organism Textmining
brain CD38-deficient strain Mus musculus
-
nerve cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the ADP-ribosyl cyclase activity shows identical properties and is inseparable, thus the enzyme is bifunctional one Mus musculus ?
-
 ?
NAD+ + H2O
-
 Mus musculus ADP-ribose + nicotinamide
-
 ?
NAD+ + H2O low activity in CD38-deficient cell membranes at all developmental stages Mus musculus ADP-ribose + nicotinamide
-
 ?

Synonyms

Synonyms Comment Organism
ADP-ribosyl cyclase/NAD+-glycohydrolase
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
32
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6
-
 in presence of EDTA Mus musculus