Literature summary for 3.2.2.29 extracted from

Mancuso, P.; Tricarico, R.; Bhattacharjee, V.; Cosentino, L.; Kadariya, Y.; Jelinek, J.; Nicolas, E.; Einarson, M.; Beeharry, N.; Devarajan, K.; Katz, R.A.; Dorjsuren, D.G.; Sun, H.; Simeonov, A.; Giordano, A.; Testa, J.R.; Davidson, G.; Davidson, I.; Larue, L.; Sobol, R.W.; Yen, T.J.; Bellacosa, A.
Thymine DNA glycosylase as a novel target for melanoma (2019), Oncogene, 38, 3710-3728 .

Search for more literature for 3.2.2.29

Application

Application	Comment	Organism
medicine	the enzyme is a highly suitable anti-melanoma drug target	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
thymine-mismatched double-stranded DNA + H2O	Homo sapiens	-	thymine + double-stranded DNA with abasic site	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Mel501 cell	-	Homo sapiens	-
melanocyte	-	Homo sapiens	-
melanoma cell	-	Homo sapiens	-
Mull cell	-	Homo sapiens	-
SK-MEL-28 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
thymine-mismatched double-stranded DNA + H2O	-	Homo sapiens	thymine + double-stranded DNA with abasic site	-	?

Subunits

Subunits	Comment	Organism
?	x * 55000, SDS-PAGE	Homo sapiens

Synonyms

Synonyms	Comment	Organism
TDG	-	Homo sapiens
thymine DNA glycosylase	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	enzyme knockdown in melanoma cell lines causes cell cycle arrest, senescence, and death by mitotic alterations, alters the transcriptome and methylome, and impairs xenograft tumor formation	Homo sapiens

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Release 2023.1 (January 2023)