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Literature summary for 3.2.2.29 extracted from
- Defining the impact of sumoylation on substrate binding and catalysis by thymine DNA glycosylase (2018), Nucleic Acids Res., 46, 5159-5170 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | sumoylation dramatically impairs the enzyme's base-excision activity, such that guanine-thymine activity is reduced by more than 45fold and 5-formylcytosine and 5-carboxylcytosine are excised slowly, with a reaction half-life of more than 9 min at 37°C | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5-carboxylcytosine-mismatched double-stranded DNA + H2O | Homo sapiens | - |
5-carboxylcytosine + double-stranded DNA with abasic site | - |
? |  |
| 5-formylcytosine-mismatched double-stranded DNA + H2O | Homo sapiens | - |
5-formylcytosine + double-stranded DNA with abasic site | - |
? | |
| thymine-mismatched double-stranded DNA + H2O | Homo sapiens | - |
thymine + double-stranded DNA with abasic site | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q13569 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| Mono Q column chromatography as final chromatographic step | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5-carboxylcytosine-mismatched double-stranded DNA + H2O | - |
Homo sapiens | 5-carboxylcytosine + double-stranded DNA with abasic site | - |
? | |
| 5-formylcytosine-mismatched double-stranded DNA + H2O | - |
Homo sapiens | 5-formylcytosine + double-stranded DNA with abasic site | - |
? | |
| thymine-mismatched double-stranded DNA + H2O | - |
Homo sapiens | thymine + double-stranded DNA with abasic site | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| TDG | - |
Homo sapiens |
| thymine DNA glycosylase | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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