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Literature summary for 3.2.2.29 extracted from
- Thymine DNA glycosylase is a positive regulator of Wnt signaling in colorectal cancer (2014), J. Biol. Chem., 289, 8881-8890.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| D133A | the mutation significantly reduces the enzymes ability to enhance Wnt signaling | Homo sapiens |
| N140A | inactive | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| nucleus | - |
Homo sapiens | 5634 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| thymine-mismatched double-stranded DNA + H2O | Homo sapiens | - |
thymine + double-stranded DNA with abasic site | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| colorectal cancer cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| thymine-mismatched double-stranded DNA + H2O | - |
Homo sapiens | thymine + double-stranded DNA with abasic site | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| TDG | - |
Homo sapiens |
| thymine DNA glycosylase | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | in colorectal cancer patients, enzyme levels are significantly higher in tumor tissues than in the adjacent normal tissues | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | enzyme knockdown by shRNAs inhibits the proliferation of colorectal cancer cells in vitro and in vivo | Homo sapiens |
| physiological function | thymine DNA glycosylase up-regulates Wnt signaling by interacting with the transcription factor TCF4 and coactivator CREB-binding protein/p300 in the Wnt pathway | Homo sapiens |
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Release 2023.1 (January 2023)
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