Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
thymine-mismatched double-stranded DNA + H2O | Homo sapiens | - |
thymine + double-stranded DNA with abasic site | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
MCF-10A cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
thymine-mismatched double-stranded DNA + H2O | - |
Homo sapiens | thymine + double-stranded DNA with abasic site | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TDG | - |
Homo sapiens |
thymine DNA glycosylase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme plays key roles in sustaining genome integrity because of its ability to selectively remove thymine from G/T mismatches through the DNA base excision repair pathway. The enzyme is actively involved in epigenetic regulation by participating in the DNA 5-methylcytosine demethylation processes | Homo sapiens |