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Literature summary for 3.2.2.29 extracted from

  • da Costa, N.M.; Hautefeuille, A.; Cros, M.P.; Melendez, M.E.; Waters, T.; Swann, P.; Hainaut, P.; Pinto, L.F.
    Transcriptional regulation of thymine DNA glycosylase (TDG) by the tumor suppressor protein p53 (2012), Cell Cycle, 11, 4570-4578.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.2.2.29

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-
nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
thymine-mismatched double-stranded DNA + H2O Homo sapiens
-
 thymine + double-stranded DNA with abasic site
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bronchial epithelial cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
thymine-mismatched double-stranded DNA + H2O
-
 Homo sapiens thymine + double-stranded DNA with abasic site
-
 ?

Subunits

Subunits Comment Organism
? x * 75000-80000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
TDG
-
 Homo sapiens
thymine DNA glycosylase
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens wild type p53 binds to a domain of the enzyme promoter containing two p53 consensus response elements and activates its transcription up