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Literature summary for 3.2.2.29 extracted from

  • Niederreither, K.; Harbers, M.; Chambon, P.; Dolle, P.
    Expression of T:G mismatch-specific thymidine-DNA glycosylase and DNA methyl transferase genes during development and tumorigenesis (1998), Oncogene, 17, 1577-1585.
    View publication on PubMed
Search for more literature for 3.2.2.29

Cloned(Commentary)

Cloned (Comment) Organism
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 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
thymine-mismatched double-stranded DNA + H2O Mus musculus DNA repair enzyme which corrects G/T mismatches that result from the hydrolytic deamination of 5-methyl cytosines thymine + double-stranded DNA with abasic site
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
bone proliferating regions of the fetal bone Mus musculus
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brain fetal, high expression Mus musculus
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fetus TDG transcripts are uniformly and ubiquitously expressed from 7.5 days post-coitum, but are then markedly enriched in specific tissues of the developing fetus. At 14.5 gestational days, TDG is strongly expressed in the developing nervous system, thymus, lung, liver, kidney and intestine. At later stages, high levels of expression were detected in the thymus, brain, nasal epithelium and within proliferating regions of the intestine, skin, kidney, teeth and bone Mus musculus
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intestine proliferating regions of the fetal intestine Mus musculus
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kidney proliferating regions of the fetal kidney Mus musculus
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additional information tumors which overexpress MMTV-v-Ha-ras or MMTV-c-myc transgenes or mice heterozygous for p53 gene disruption, all show elevated TDG and methyl transferase expression specific to the transformed tissue Mus musculus
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olfactory epithelium fetal, high expression Mus musculus
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skin proliferating regions of the fetal skin Mus musculus
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thymus fetal, high expression Mus musculus
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tooth proliferating regions of the fetal teeth Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
thymine-mismatched double-stranded DNA + H2O DNA repair enzyme which corrects G/T mismatches that result from the hydrolytic deamination of 5-methyl cytosines Mus musculus thymine + double-stranded DNA with abasic site
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 ?

Synonyms

Synonyms Comment Organism
T:G mismatch-specific thymidine-DNA glycosylase
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 Mus musculus
TDG
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 Mus musculus