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Literature summary for 3.2.2.29 extracted from
- Thymine DNA glycosylase represses myocardin-induced smooth muscle cell differentiation by competing with serum response factor for myocardin binding. (2008), J. Biol. Chem., 283, 35383-35392.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | TDG can inhibit expression of smooth muscle-specific genes, at least in part, through disrupting serum response factor/myocardin interactions. The glycosylase activity of TDG is not required for its inhibitory effects on myocardin function. Role for the repair enzyme TDG as a repressor of smooth muscle differentiation via competing with serum response factor for binding to myocardin | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | TDG can inhibit expression of smooth muscle-specific genes, at least in part, through disrupting serum response factor/myocardin interactions. The glycosylase activity of TDG is not required for its inhibitory effects on myocardin function. Role for the repair enzyme TDG as a repressor of smooth muscle differentiation via competing with serum response factor for binding to myocardin | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| TDG | - |
Mus musculus |
| thymine DNA glycosylase | - |
Mus musculus |
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Release 2023.1 (January 2023)
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