Any feedback?
Literature summary for 3.2.2.29 extracted from
- Substrate specificity of human thymine-DNA glycosylase on exocyclic cytosine adducts (2007), Chem. Biol. Interact., 165, 230-238.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | the enzyme can be stimulated by human AP endonuclease 1 | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q13569 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 8-(hydroxymethyl)-3,N4-ethenocytosine-mismatched double-stranded DNA + H2O | TDG is able to excise the 8-(hydroxymethyl)-3,N4-ethenocytosine from DNA. TDG activity displays a marked preference of guanine opposite to 8-(hydroxymethyl)-3,N4-ethenocytosine over any other bases. TDG does not show any detectable activity toward 3,N4-ethanocytosine when placed in various neighboring sequences, including the 5'-CpG site | Homo sapiens | 8-(hydroxymethyl)-3,N4-ethenocytosine + double-stranded DNA with abasic site | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| TDG | - |
Homo sapiens |
| thymine-DNA glycosylase | - |
Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
