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Literature summary for 3.2.2.27 extracted from

  • Herate, C.; Vigne, C.; Guenzel, C.A.; Lambele, M.; Rouyez, M.C.; Benichou, S.
    Uracil DNA glycosylase interacts with the p32 subunit of the replication protein A complex to modulate HIV-1 reverse transcription for optimal virus dissemination (2016), Retrovirology, 13, 26 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.2.2.27

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
HEK-293T cell
-
 Homo sapiens
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HeLa cell
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 Homo sapiens
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JURKAT cell
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 Homo sapiens
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monocyte-derived macrophage
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 Homo sapiens
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peripheral blood mononuclear cell
-
 Homo sapiens
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Synonyms

Synonyms Comment Organism
UNG2 isoform Homo sapiens
uracil DNA glycosylase 2
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction human immunodeficiency virus-1 infectivity and replication in peripheral blood mononuclear cells and monocyte-derived macrophages as well as the efficiency of the viral DNA synthesis are significantly reduced when viruses are produced from cells depleted of endogenous enzyme Homo sapiens
physiological function the enzyme interacts with the p32 subunit of the replication protein A complex to modulate human immunodeficiency virus-1 reverse transcription for optimal virus dissemination Homo sapiens