Protein Variants | Comment | Organism |
---|---|---|
DELTA90 | the mutant shows about 180 of wild type uracil removal activity | Mus musculus |
DELTA90/W231A | the mutant less than 20% of wild type uracil removal activity | Mus musculus |
W231A | the mutant shows about 20% of wild type uracil removal activity | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
uracil-mismatched DNA + H2O | Mus musculus | - |
uracil + DNA with abasic site | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
B-lymphocyte | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
uracil-mismatched DNA + H2O | - |
Mus musculus | uracil + DNA with abasic site | - |
? |
Synonyms | Comment | Organism |
---|---|---|
UNG | - |
Mus musculus |
uracil DNA glycosylase | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme deficiency enhances translesion polymerase recruitment and inhibits S-S synapse formation during class switch recombination | Mus musculus |
physiological function | the noncanonical function of the enzyme regulates the steps after activation-induced cytidine deaminase-induced DNA cleavage: errorprone repair suppression in S region somatic hypermutation and end-joining promotion in class switch recombination | Mus musculus |