Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.2.2.27 extracted from

  • Yousif, A.S.; Stanlie, A.; Mondal, S.; Honjo, T.; Begum, N.A.
    Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase (2014), Proc. Natl. Acad. Sci. USA, 111, E1016-E1024.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
DELTA90 the mutant shows about 180 of wild type uracil removal activity Mus musculus
DELTA90/W231A the mutant less than 20% of wild type uracil removal activity Mus musculus
W231A the mutant shows about 20% of wild type uracil removal activity Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
uracil-mismatched DNA + H2O Mus musculus
-
uracil + DNA with abasic site
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
B-lymphocyte
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
uracil-mismatched DNA + H2O
-
Mus musculus uracil + DNA with abasic site
-
?

Synonyms

Synonyms Comment Organism
UNG
-
Mus musculus
uracil DNA glycosylase
-
Mus musculus

General Information

General Information Comment Organism
malfunction enzyme deficiency enhances translesion polymerase recruitment and inhibits S-S synapse formation during class switch recombination Mus musculus
physiological function the noncanonical function of the enzyme regulates the steps after activation-induced cytidine deaminase-induced DNA cleavage: errorprone repair suppression in S region somatic hypermutation and end-joining promotion in class switch recombination Mus musculus