Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21(DE3) cells | Danio rerio |
Protein Variants | Comment | Organism |
---|---|---|
D132A | inactive | Danio rerio |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Danio rerio | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
uracil-mismatched double-stranded DNA + H2O | Danio rerio | - |
uracil + double-stranded DNA with abasic site | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Danio rerio | - |
- |
- |
Purification (Comment) | Organism |
---|---|
Ni-NTA column chromatography | Danio rerio |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blastomere | - |
Danio rerio | - |
egg | - |
Danio rerio | - |
embryo | - |
Danio rerio | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
uracil-mismatched double-stranded DNA + H2O | - |
Danio rerio | uracil + double-stranded DNA with abasic site | - |
? |
Synonyms | Comment | Organism |
---|---|---|
UDG | - |
Danio rerio |
Unga | isoform | Danio rerio |
uracil-DNA glycosylase a | isoform | Danio rerio |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme knockdown in the zebrafish embryo increases global DNA methylation level, inhibits transcription, and causes embryonic lethality | Danio rerio |
physiological function | uracil-DNA glycosylase is involved in postfertilization genomic DNA demethylation and zygotic gene transcription and is required for normal embryonic development in the zebrafish embryo. Enzyme-mediated DNA demethylation facilitates histone modifications of chromatin in zebrafish embryos | Danio rerio |