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Literature summary for 3.2.2.27 extracted from

  • Yousif, A.S.; Stanlie, A.; Begum, N.A.; Honjo, T.
    Opinion: uracil DNA glycosylase (UNG) plays distinct and non-canonical roles in somatic hypermutation and class switch recombination (2014), Int. Immunol., 26, 575-578.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.2.2.27

Protein Variants

Protein Variants Comment Organism
D145N the mutant shows increased class switch recombination efficiency and reduced uracil removal activity compared to the wild type enzyme Mus musculus
DELTA90/W231A the mutant shows reduced class switch recombination efficiency and reduced deoxyuracil removal activity compared to the wild type enzyme Mus musculus
H268L the mutant shows increased class switch recombination efficiency and reduced deoxyuracil removal activity compared to the wild type enzyme Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
uracil-mismatched single-stranded DNA + H2O Mus musculus
-
 uracil + single-stranded DNA with abasic site
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
uracil-mismatched single-stranded DNA + H2O
-
 Mus musculus uracil + single-stranded DNA with abasic site
-
 ?

Synonyms

Synonyms Comment Organism
UNG
-
 Mus musculus
uracil DNA glycosylase
-
 Mus musculus

General Information

General Information Comment Organism
physiological function the DNA base excision repair enzyme is essential for class switch recombination Mus musculus