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Literature summary for 3.2.2.27 extracted from

  • Schonhoft, J.D.; Kosowicz, J.G.; Stivers, J.T.
    DNA translocation by human uracil DNA glycosylase: role of DNA phosphate charge (2013), Biochemistry, 52, 2526-2535.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
uracil-mismatched double-stranded DNA + H2O Homo sapiens
-
uracil + double-stranded DNA with abasic site
-
?
uracil-mismatched single-stranded DNA + H2O Homo sapiens
-
uracil + single-stranded DNA with abasic site
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme primarily interacts with the phosphate backbone on the single strand of DNA. The enzyme does not require a continuous polyanion DNA strand Homo sapiens ?
-
?
uracil-mismatched double-stranded DNA + H2O
-
Homo sapiens uracil + double-stranded DNA with abasic site
-
?
uracil-mismatched single-stranded DNA + H2O
-
Homo sapiens uracil + single-stranded DNA with abasic site
-
?

Synonyms

Synonyms Comment Organism
UNG
-
Homo sapiens
uracil DNA glycosylase
-
Homo sapiens