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Literature summary for 3.2.2.27 extracted from

  • Fenard, D.; Houzet, L.; Bernard, E.; Tupin, A.; Brun, S.; Mougel, M.; Devaux, C.; Chazal, N.; Briant, L.
    Uracil DNA glycosylase 2 negatively regulates HIV-1 LTR transcription (2009), Nucleic Acids Res., 37, 6008-6018.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.2.2.27

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of UNG2 inhibits HIV-1 replication Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
CCRF-CEM cell
-
 Homo sapiens
-
HEK-293T cell
-
 Homo sapiens
-
HeLa LTRHIV-1-Luc cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
UNG2
-
 Homo sapiens
uracil DNA glycosylase 2
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens depletion of endogenous UNG2 is proteasome-dependent and requires a direct interaction with HIV Vpr but not with integrase, different capacity between HIV-1 and HIV-2 to inhibit intracellular UNG2 expression down

General Information

General Information Comment Organism
metabolism UNG2 is a major determinant of the uracil base excision repair pathway, that undergoes rapid proteasome-dependent degradation following HIV-1 infection Homo sapiens
physiological function uracil DNA glycosylase 2 negatively regulates HIV-1 LTR transcription, and shows antiviral activity at the transcriptional level requiring the integrity of its catalytic domain, depletion of endogenous UNG2 promotes Tat-mediated LTR transcription, molecular mechanisms, overview Homo sapiens