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Literature summary for 3.2.2.27 extracted from
- Uracil DNA glycosylase uses DNA hopping and short-range sliding to trap extrahelical uracils (2008), Proc. Natl. Acad. Sci. USA, 105, 10791-10796.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | kinetics | Escherichia coli |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| uracil-mismatched double-stranded DNA + H2O | Escherichia coli | - |
uracil + double-stranded DNA with abasic site | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | UNG removes uracil from DNA, substrate recognition and catalytic reaction mechanism, short-range sliding is vital for extrahelical uracil trapping, intramolecular transfer mechanisms of the enzyme, detailed overview | Escherichia coli | ? | - |
? | |
| uracil-mismatched double-stranded DNA + H2O | - |
Escherichia coli | uracil + double-stranded DNA with abasic site | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| UNG | - |
Escherichia coli |
| uracil DNA glycosylase | - |
Escherichia coli |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Escherichia coli |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Escherichia coli |
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Release 2023.1 (January 2023)
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