Literature summary for 3.2.2.23 extracted from

Minko, I.G.; Christov, P.P.; Li, L.; Stone, M.P.; McCullough, A.K.; Lloyd, R.S.
Processing of N5-substituted formamidopyrimidine DNA adducts by DNA glycosylases NEIL1 and NEIL3 (2019), DNA Repair, 73, 49-54 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q96FI4	cf. EC 4.2.99.18	-
Mus musculus	Q8K203	cf. EC 4.2.99.18	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ds oligodeoxynucleotides containing N5-alkyl formamidopyrimidine + H2O	-	Homo sapiens	2,6-diamino-4-hydroxy-5-formamidopyrimidine + ds oligonucleotide	-	?
additional information	the mouse enzyme cannot initiate repair of aflatoxin B1-induced DNA base alkylation damage in either ds or ss DNA	Mus musculus	?	-	?
ss oligodeoxynucleotides containing N5-alkyl formamidopyrimidine + H2O	DNA base alkylation damage induced by nitrogen mustard	Mus musculus	2,6-diamino-4-hydroxy-5-formamidopyrimidine + ds oligonucleotide	-	?

Synonyms

Synonyms	Comment	Organism
NEIL1	-	Homo sapiens
NEIL3	-	Mus musculus

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Release 2023.1 (January 2023)