Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | P05523 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
53mer containing 8-oxoguanine + H2O | - |
Escherichia coli | 53mer with an abasic site + 8-oxoguanine | - |
? |
General Information | Comment | Organism |
---|---|---|
physiological function | nucleoid-associated protein HU enhances the 8-oxoguanine-DNA glycosylase activity of Fpg by facilitating the release of the enzyme from its final DNA product. The displacement of Fpg from its end-DNA product by HU is an active mechanism in which HU recognizes the product when it is still bound by Fpg. The two proteins form a transient ternary complex Fpg/DNA/HU which results in the release of Fpg and the molecular entrapment of single-strand breaks by HU | Escherichia coli |