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Literature summary for 3.2.2.23 extracted from

  • Jaruga, P.; Xiao, Y.; Vartanian, V.; Lloyd, R.S.; Dizdaroglu, M.
    Evidence for the involvement of DNA repair enzyme NEIL1 in nucleotide excision repair of (5'R)- and (5'S)-8,5'-cyclo-2'-deoxyadenosines (2010), Biochemistry, 49, 1053-1055.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
liver
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Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA containing 2,6-diamino-4-hydroxy-5-formamidopyrimidine residues + H2O
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Mus musculus DNA + 2,6-diamino-4-hydroxy-5-formamidopyrimidine
-
?
DNA containing 4,6-diamino-5-formamidopyrimidine residues + H2O
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Mus musculus 4,6-diamino-5-formamidopyrimidine + DNA
-
?
additional information the enzyme has no specificity for DNA containing 8-hydroxyguanine residues Mus musculus ?
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?

Synonyms

Synonyms Comment Organism
NEIL1
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Mus musculus

General Information

General Information Comment Organism
malfunction there is significant accumulation of 2,6-diamino-4-hydroxy-5-formamidopyrimidine, (5'R)-8,5'-cyclo-2'-deoxyadenosine and (5'S)-8,5'-cyclo-2'-deoxyadenosine in liver DNA of neil1knockout mice that are not exposed to exogenous oxidative stress Mus musculus
physiological function NEIL1 is a DNA glycosylase that is involved in the first step of base excision repair of oxidatively induced DNA damage. NEIL1 is involved in nucleotide excision repair of (5'R)-8,5'-cyclo-2'-deoxyadenosine and (5'S)-8,5'-cyclo-2'-deoxyadenosine Mus musculus