Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA containing 2,6-diamino-4-hydroxy-5-formamidopyrimidine residues + H2O | - |
Mus musculus | DNA + 2,6-diamino-4-hydroxy-5-formamidopyrimidine | - |
? | |
DNA containing 4,6-diamino-5-formamidopyrimidine residues + H2O | - |
Mus musculus | 4,6-diamino-5-formamidopyrimidine + DNA | - |
? | |
additional information | the enzyme has no specificity for DNA containing 8-hydroxyguanine residues | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NEIL1 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | there is significant accumulation of 2,6-diamino-4-hydroxy-5-formamidopyrimidine, (5'R)-8,5'-cyclo-2'-deoxyadenosine and (5'S)-8,5'-cyclo-2'-deoxyadenosine in liver DNA of neil1knockout mice that are not exposed to exogenous oxidative stress | Mus musculus |
physiological function | NEIL1 is a DNA glycosylase that is involved in the first step of base excision repair of oxidatively induced DNA damage. NEIL1 is involved in nucleotide excision repair of (5'R)-8,5'-cyclo-2'-deoxyadenosine and (5'S)-8,5'-cyclo-2'-deoxyadenosine | Mus musculus |