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Literature summary for 3.2.2.23 extracted from

  • Muftuoglu, M.; de Souza-Pinto, N.C.; Dogan, A.; Aamann, M.; Stevnsner, T.; Rybanska, I.; Kirkali, G.; Dizdaroglu, M.; Bohr, V.A.
    Cockayne syndrome group B protein stimulates repair of formamidopyrimidines by NEIL1 DNA glycosylase (2009), J. Biol. Chem., 284, 9270-9279.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.2.2.23

Activating Compound

Activating Compound Comment Organism Structure
complementation groups B genes CSB stimulates incision activity of NEIL1 Mus musculus
complementation groups B genes CSB stimulates incision activity of NEIL1, and CSB stimulates the NEIL1-mediated AP lyase activity 3fold Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Mus musculus 5739
-
mitochondrion
-
 Homo sapiens 5739
-
nucleus
-
 Mus musculus 5634
-
nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus NEIL1 is active on DNA lesions in ssDNA, particularly in the context of a single-stranded bubble in a duplex sequence ?
-
 ?
additional information Homo sapiens NEIL1 is active on DNA lesions in ssDNA, particularly in the context of a single-stranded bubble in a duplex sequence ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-
liver
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information NEIL1 is active on DNA lesions in ssDNA, particularly in the context of a single-stranded bubble in a duplex sequence Mus musculus ?
-
 ?
additional information NEIL1 is active on DNA lesions in ssDNA, particularly in the context of a single-stranded bubble in a duplex sequence Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
endonuclease VIII-like DNA glycosylase
-
 Mus musculus
endonuclease VIII-like DNA glycosylase
-
 Homo sapiens
NEIL1
-
 Mus musculus
NEIL1
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus
37
-
 assay at Homo sapiens

General Information

General Information Comment Organism
malfunction csb-/- mice with Cockayne syndrome, a segmental premature aging syndrome with progressive neurological degeneration caused by mutations in CS complementation groups A, CSA, or B, CSB, genes, show increased 2,6-diamino-4-hydroxy-5-formamidopyrimidine and 4,6-diamino-5-formamidopyrimidine concentrations in in genomic DNA and mtDNA, and reduced repair function due to mutation of the endonuclease VIII-like DNA glycosylase NEIL1, overview Mus musculus
malfunction patients with Cockayne syndrome, a segmental premature aging syndrome with progressive neurological degeneration caused by mutations in CS complementation groups A, CSA, or B, CSB, genes, show increased 2,6-diamino-4-hydroxy-5-formamidopyrimidine and 4,6-diamino-5-formamidopyrimidine concentrations in in genomic DNA and mtDNA, and reduced repair function due to mutation of the endonuclease VIII-like DNA glycosylase NEIL1, overview Homo sapiens
physiological function NEIL1 plays a role during transcription Mus musculus
physiological function NEIL1 plays a role during transcription Homo sapiens