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Literature summary for 3.2.2.23 extracted from

  • Lacoste, S.; Castonguay, A.; Drouin, R.
    Repair kinetics of specific types of nitroso-induced DNA damage using the comet assay in human cells (2007), Mutat. Res., 624, 18-30.
    View publication on PubMed

Application

Application Comment Organism
analysis DNA repair kinetics can be investigated with the comet assay and differences between cell types can be observed Homo sapiens
medicine treatment of cells with 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone generates formamidopyrimidine glycosylase sensitive DNA sites with cell-type dependent differences in adduct frequency and time Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
Homo sapiens
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lymphocyte
-
Homo sapiens
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NCI-H23 cell
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Homo sapiens
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U-937 cell
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Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information treatment of cells with 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone generates formamidopyrimidine glycosylase sensitive DNA sites with cell-type dependent differences in adduct frequency and time Homo sapiens ?
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