Literature summary for 3.2.2.23 extracted from

Buchko, G.W.; Hess, N.J.; Bandaru, V.; Wallace, S.S.; Kennedy, M.A.
Spectroscopic studies of zinc(II)- and cobalt(II)-associated Escherichia coli formamidopyrimidine-DNA glycosylase: extended X-ray absorption fine structure evidence for a metal-binding domain (2000), Biochemistry, 39, 12441-12449.

Search for more literature for 3.2.2.23

Crystallization (Commentary)

Crystallization (Comment)	Organism
structures of zinc- and cobalt-associated enzyme	Escherichia coli

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Co2+	zinc(II)- and cobalt(II)-associated enzyme, metal-binding domain	Escherichia coli
Zn2+	zinc(II)- and cobalt(II)-associated enzyme, metal-binding domain, zinc-associated motif is located at the C-terminus and essential for damaged DNA recognition	Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
DNA + H2O	Escherichia coli	plays an important role in base excision repair of oxidatively damaged DNA	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
DNA + H2O	plays an important role in base excision repair of oxidatively damaged DNA	Escherichia coli	?	-	?
DNA containing 8-hydroxyguanine residues + H2O	7,8-dihydro-8-oxoguanine-DNA	Escherichia coli	8-hydroxyguanine + DNA	-	?
DNA containing 8-hydroxyguanine residues + H2O	54 nt DNA oligomer, CoFpg and ZnFpg are equally active at cleaving the DNA at the site of the oxidized guanine	Escherichia coli	8-hydroxyguanine + DNA	-	?

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Release 2023.1 (January 2023)