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Literature summary for 3.2.2.22 extracted from

  • Citores, L.; Iglesias, R.; Gay, C.; Ferreras, J.M.
    Antifungal activity of the ribosome-inactivating protein BE27 from sugar beet (Beta vulgaris L.) against the green mould Penicillium digitatum (2016), Mol. Plant Pathol., 17, 261-271 .
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining
apoplast
-
 Beta vulgaris subsp. vulgaris 48046
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Organism

Organism UniProt Comment Textmining
Beta vulgaris subsp. vulgaris Q5QHN9
-
-

Source Tissue

Source Tissue Comment Organism Textmining
leaf
-
 Beta vulgaris subsp. vulgaris
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Synonyms

Synonyms Comment Organism
BE27
-
 Beta vulgaris subsp. vulgaris
ribosome-inactivating protein
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 Beta vulgaris subsp. vulgaris

General Information

General Information Comment Organism
physiological function BE27 displays antifungal activity against the green mould Penicillium digitatum. BE27 is able to enter into the cytosol and kill fungal cells. The mechanism of action seems to involve ribosomal RNA N-glycosylase activity on the sarcin-ricin loop of the major rRNA which inactivates irreversibly the fungal ribosomes. A structural motif composed of an alpha-helix and a beta-hairpin at the C-terminus of BE27 might contribute to the interaction with the fungal plasma membranes Beta vulgaris subsp. vulgaris