Literature summary for 3.2.2.22 extracted from

Weng, A.; Bachran, C.; Fuchs, H.; Krause, E.; Stephanowitz, H.; Melzig, M.F.
Enhancement of saporin cytotoxicity by Gypsophila saponins - more than stimulation of endocytosis (2009), Chem. Biol. Interact., 181, 424-429.

Search for more literature for 3.2.2.22

Activating Compound

Activating Compound	Comment	Organism	Structure
saponins	e.g. from Saponinum album and Gypsophila paniculata, enhance saporin's cytotoxicity against ECV-304 cells, overview	Saponaria officinalis

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
28S rRNA + H2O	Saponaria officinalis	saporin is a type I ribosome-inactivating protein with N-glycosidase activity. It removes adenine residues from the 28S ribosomal RNA resulting in inhibition of protein synthesis	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Saponaria officinalis	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
28S rRNA + H2O	saporin is a type I ribosome-inactivating protein with N-glycosidase activity. It removes adenine residues from the 28S ribosomal RNA resulting in inhibition of protein synthesis	Saponaria officinalis	?	-	?

Synonyms

Synonyms	Comment	Organism
rRNA N-glycosidase	-	Saponaria officinalis
saporin	-	Saponaria officinalis
type I ribosome-inactivating protein	-	Saponaria officinalis

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Release 2023.1 (January 2023)