Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli JM 101 | Ricinus communis |
Crystallization (Comment) | Organism |
---|---|
RTA with 4-(3-(2-amino-4,6-dihydroxy-5-pyrimidinyl)propyl) benzoic acid | Ricinus communis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
((5-(2-amino-4,6-dihydroxy-5-pyrimidinyl)pentanoyl)amino)acetic acid | - |
Ricinus communis | |
2-amino-1,4-dihydro-6-hydroxy-4-oxo-5-pyrimidinepentanoic acid | - |
Ricinus communis | |
2-amino-1,4-dihydro-6-hydroxy-4-oxo-a-phenyl-pyrimidinepentanoic acid | PPA | Ricinus communis | |
4-(3-(2-amino-1,4-dihydro-6-hydroxy-4-oxo-5-pyrimidinyl)propyl)-benzoic acid | PBA | Ricinus communis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
28S rRNA + H2O | Ricinus communis | depurination or 28S rRNA, removal of adenine from rRNA, inactivating ribosomal function in translation | 28S rRNA fragment + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Ricinus communis | P02879 | castor | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
80% inhibition of protein synthesis in rabbit reticulocyte luciferase control RNA assay with 0.2 nM RTA | Ricinus communis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
28S rRNA + H2O | depurination or 28S rRNA, removal of adenine from rRNA, inactivating ribosomal function in translation | Ricinus communis | 28S rRNA fragment + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
RTA | A-chain of ricin with enzymatic activity | Ricinus communis |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
additional information | - |
> 1 mM | Ricinus communis | 2-amino-1,4-dihydro-6-hydroxy-4-oxo-a-phenyl-pyrimidinepentanoic acid | |
additional information | - |
> 3 mM | Ricinus communis | 2-amino-1,4-dihydro-6-hydroxy-4-oxo-5-pyrimidinepentanoic acid | |
0.27 | - |
30°C | Ricinus communis | 4-(3-(2-amino-1,4-dihydro-6-hydroxy-4-oxo-5-pyrimidinyl)propyl)-benzoic acid | |
2 | - |
- |
Ricinus communis | ((5-(2-amino-4,6-dihydroxy-5-pyrimidinyl)pentanoyl)amino)acetic acid |