Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.2.2.22 extracted from

  • Bai, Y.; Monzingo, A.F.; Robertus, J.D.
    The X-ray structure of ricin A chain with a novel inhibitor (2009), Arch. Biochem. Biophys., 483, 23-28.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli JM 101 Ricinus communis

Crystallization (Commentary)

Crystallization (Comment) Organism
RTA with 4-(3-(2-amino-4,6-dihydroxy-5-pyrimidinyl)propyl) benzoic acid Ricinus communis

Inhibitors

Inhibitors Comment Organism Structure
((5-(2-amino-4,6-dihydroxy-5-pyrimidinyl)pentanoyl)amino)acetic acid
-
Ricinus communis
2-amino-1,4-dihydro-6-hydroxy-4-oxo-5-pyrimidinepentanoic acid
-
Ricinus communis
2-amino-1,4-dihydro-6-hydroxy-4-oxo-a-phenyl-pyrimidinepentanoic acid PPA Ricinus communis
4-(3-(2-amino-1,4-dihydro-6-hydroxy-4-oxo-5-pyrimidinyl)propyl)-benzoic acid PBA Ricinus communis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
28S rRNA + H2O Ricinus communis depurination or 28S rRNA, removal of adenine from rRNA, inactivating ribosomal function in translation 28S rRNA fragment + ?
-
?

Organism

Organism UniProt Comment Textmining
Ricinus communis P02879 castor
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
80% inhibition of protein synthesis in rabbit reticulocyte luciferase control RNA assay with 0.2 nM RTA Ricinus communis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
28S rRNA + H2O depurination or 28S rRNA, removal of adenine from rRNA, inactivating ribosomal function in translation Ricinus communis 28S rRNA fragment + ?
-
?

Synonyms

Synonyms Comment Organism
RTA A-chain of ricin with enzymatic activity Ricinus communis

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
additional information
-
> 1 mM Ricinus communis 2-amino-1,4-dihydro-6-hydroxy-4-oxo-a-phenyl-pyrimidinepentanoic acid
additional information
-
> 3 mM Ricinus communis 2-amino-1,4-dihydro-6-hydroxy-4-oxo-5-pyrimidinepentanoic acid
0.27
-
30°C Ricinus communis 4-(3-(2-amino-1,4-dihydro-6-hydroxy-4-oxo-5-pyrimidinyl)propyl)-benzoic acid
2
-
-
Ricinus communis ((5-(2-amino-4,6-dihydroxy-5-pyrimidinyl)pentanoyl)amino)acetic acid