Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
9567 | - |
MALDI-TOF MS, SDS-PAGE | Hypsizygus marmoreus |
10000 | - |
1 * 10000, SDS-PAGE | Hypsizygus marmoreus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
28S rRNA + H2O | Hypsizygus marmoreus | depurination at A4324, removal of adenine from rRNA, inactivating ribosomal function in translation | 28S rRNA fragment + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Hypsizygus marmoreus | - |
mushroom, comparison with ribosome inhibitory proteins of bitter gourd, hairy gourd, ridge gourd, garden pea, Flammulina velutipes (mushroom with velutin) | - |
Purification (Comment) | Organism |
---|---|
centrifugation of homogenized fruiting bodies followed by ion exchange chromatography on a diethylaminoethyl-cellulose column in 10 mM Tris-HCl buffer, pH 7, Affi-gel blue gel column chromatography of unabsorbed protein fraction (with translation-inhibiting activity) in 10 mM Tris-HCl buffer, pH 7 yields bound marmorin | Hypsizygus marmoreus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
mushroom body | fresh fruiting | Hypsizygus marmoreus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
marmorin inhibits proliferation of hepatoma Hep G2 cells (IC50 = 0.00015 mM), breast cancer MCF-7 cells (IC50 = 0.005 mM), HIV-1 reverse transcriptase activity (IC50 = 0.03 mM), and translation in the rabbit reticulocyte lysate system (IC50 = 0.0000007 mM), no inhibitory action on embryonic liver WRL-68 cells, no antifungal, mitogenic/antimitogenic, protease, protease inhibitory, RNase, and nitric oxide-inducing activities | Hypsizygus marmoreus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
28S rRNA + H2O | depurination at A4324, removal of adenine from rRNA, inactivating ribosomal function in translation | Hypsizygus marmoreus | 28S rRNA fragment + ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 10000, SDS-PAGE | Hypsizygus marmoreus |
Synonyms | Comment | Organism |
---|---|---|
marmorin | - |
Hypsizygus marmoreus |
ribosome inactivating protein | - |
Hypsizygus marmoreus |