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Literature summary for 3.2.2.22 extracted from

  • Zheng, J.; Cui, S.; Teel, L.D.; Zhao, S.; Singh, R.; OBrien, A.D.; Meng, J.
    Identification and characterization of Shiga toxin type 2 variants in Escherichia coli isolates from animals, food, and humans (2008), Appl. Environ. Microbiol., 74, 5645-5652.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
diagnostics identification of highly toxic Escherichia coli variants in humans, animals, and food by using primer homologous to the elastase recognition site of Stx2dact or other variants Escherichia coli

Protein Variants

Protein Variants Comment Organism
additional information elastase increases cytotoxicity of Shiga toxin type 2 by cleaving 2 amino acids of toxin subunit A rendering it more toxic Escherichia coli
additional information P1130 and stx1 deletion mutants of CVM9322, CVM9557, and CVM9584 show 13-30-fold increased Vero cell cytotoxicities after treatment with porcine pancreatic elastase Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli Q8KTU8 Shiga toxin 2A subunit; STEC (Shiga toxin producing Escherichia coli) isolates from cows, meat, human
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Synonyms

Synonyms Comment Organism
Shiga toxin variant Stx2dact (mucus-activatable Shiga toxin type 2), elastase cleaves 2 amino acids of toxin subunit A rendering it more toxic Escherichia coli
Shiga toxin type 2
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Escherichia coli
Stx2
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Escherichia coli
Stx2dact variant of Shiga toxin type 2 Escherichia coli